HTLV-1 associated adult T-cell leukemia/lymphoma in Israel: report of two patients of Romanian origin

Department of Hematology, Kaplan Medical Center, Rehovot, 76100, Israel. Human T-lymphotropic virus type 1 (HTLV-1) was the first human oncovirus isolated by Gallo et al. in 1980 and established as an etiological agent for adult T-cell leukemia/ lymphoma (ATL). Although more than 15 million individu...

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Bibliographic Details
Published in:Haematologica (Roma) 2005-03, Vol.90 (3), p.ECR13-ECR13
Main Authors: Shtalrid, M, Shvidel, L, Korenfeld, R, Duek, A, Landau, Z, Berrebi, A
Format: Article
Language:English
Subjects:
Family Health
Humans
Infectious Disease Transmission, Vertical
Israel - epidemiology
Jews
Leukemia-Lymphoma, Adult T-Cell - epidemiology
Leukemia-Lymphoma, Adult T-Cell - ethnology
Leukemia-Lymphoma, Adult T-Cell - transmission
Romania - ethnology
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Summary:Department of Hematology, Kaplan Medical Center, Rehovot, 76100, Israel. Human T-lymphotropic virus type 1 (HTLV-1) was the first human oncovirus isolated by Gallo et al. in 1980 and established as an etiological agent for adult T-cell leukemia/ lymphoma (ATL). Although more than 15 million individuals are infected by HTLV-1 through the world, the spread of the virus is highly endemic. The HTLV-1 infection is prevailing in southwestern Japan, inter-tropical Africa, Central and South America. In Kyushu district, Japan, the seroprevalence reaches >30% in the adult population. In the US, Europe and the Middle East the HTLV-1 infection is very rare, and cases of ATL have been reported sporadically. We describe here acute ATL in two patients of Jewish- Romanian origin. The epidemiological anamnesis and screening indicate that both patients acquired the HTLV-1 from their mothers leaving in Romania.
ISSN:0390-6078
1592-8721