Target Discovery Process

In order to minimise attrition rates in drug development projects, a target discovery process is implemented to select and characterise the most suitable candidate kinase targets, before lead identification and lead optimisation are embarked upon. The process consists of 1) target selection, 2) targ...

Full description

Saved in:
Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2005-03, Vol.6 (3), p.468-479
Main Authors: Egner, Ursula, Krätzschmar, Jörn, Kreft, Bertolt, Pohlenz, Hans-Dieter, Schneider, Martin
Format: Article
Language:English
Subjects:
Drug Design
Drug Evaluation, Preclinical
functional genomics
gene technology
Humans
Oligonucleotide Array Sequence Analysis
protein structures
Proteins - antagonists & inhibitors
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Substrate Specificity
target discovery
target validation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In order to minimise attrition rates in drug development projects, a target discovery process is implemented to select and characterise the most suitable candidate kinase targets, before lead identification and lead optimisation are embarked upon. The process consists of 1) target selection, 2) target assessment, and 3) target validation. This rational approach to target discovery, as a prerequisite for lead discovery, ensures that new therapeutic targets fulfil a set of general criteria, as well as indication-specific, descriptive and functional ones. The approach should ultimately maximise the likelihood of achieving target-selective inhibition by small-molecule inhibitors with minimal in vivo side effects and a therapeutic effect based on a sound biological hypothesis.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200400158