Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum

The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the he...

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Bibliographic Details
Published in:Fitoterapia 2005-03, Vol.76 (2), p.187-193
Main Authors: Yemitan, O.K., Salahdeen, H.M.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anticonvulsant
Anticonvulsants - administration & dosage
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Behavior, Animal - drug effects
Biological and medical sciences
Bryophyllum pinnatum
Crassulaceae
Dose-Response Relationship, Drug
Exploratory Behavior - drug effects
Female
General pharmacology
Male
Medical sciences
Mice
Muscle relaxant
Neuromuscular Blocking Agents - administration & dosage
Neuromuscular Blocking Agents - pharmacology
Neuromuscular Blocking Agents - therapeutic use
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
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Summary:The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the head-dip and evasion tests. Moreover, a dose-dependent muscle in-coordination was observed in the inclined screen, traction and climbing tests. It delayed onset to convulsion in both strychnine- and picrotoxin-induced seizures in addition to minimal protection against picrotoxin seizures.
ISSN:0367-326X
DOI:10.1016/j.fitote.2004.11.009