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Effect of an OT antagonist on the control of the midcycle LH surge in women
Summary Objective Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re‐examined this matter in women with a fully characterized midcycle LH surge. Design Normal women were...
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| Published in: | Clinical endocrinology (Oxford) 2009-07, Vol.71 (1), p.100-103 |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Vanakara, P. Dafopoulos, K. Papastergiopoulou, L. Kallitsaris, A. Papageorgiou, I. Messinis, I. E. |
| description | Summary
Objective Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re‐examined this matter in women with a fully characterized midcycle LH surge.
Design Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16–17 mm (Group 1) or 18–19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle‐1) or atosiban (cycle‐2).
Patients Fifteen women (10 in group 1 and 5 in group 2) aged 23–35 years.
Measurements Blood samples were obtained every 6 h to characterize the midcycle LH surge.
Results The time interval (mean ± SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46·8 ± 4·8 and 45·6 ± 9·6 h in group 1 and 6·0 ± 2·4 and 7·5 ± 2·8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle‐2 (41·2 ± 4·6 mIU/ml) was significantly lower than in cycle‐1 (52·8 ± 3·4 mIU/ml, P |
| doi_str_mv | 10.1111/j.1365-2265.2008.03456.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67496970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67496970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4356-ead48513062fe02ee72202c5bd0e450ca7fb2e5f372a4143b172ed6c8df96ad63</originalsourceid><addsrcrecordid>eNqNkUtvEzEURi0EomnhLyBvYDfTa3tszyxYoCi0VaN0E2BpOZ7rMmEexZ6oyb_HQ6J0Wy_8PJ8fx4RQBjlL5XqbM6FkxrmSOQcocxCFVPn-DZmdF96SGQiADJQqLshljFsAkCXo9-SCVUyXUsCM3C-8RzfSwVPb04d1qkf7OPRNTHM9HX8jdUM_hqGdkGnYNbU7uBbp8pbGXXhE2vT0eeiw_0DeedtG_Hhqr8iP74v1_DZbPtzczb8tM1cIqTK0dVFKJkBxj8ARNefAndzUgIUEZ7XfcJReaG4LVogN0xxr5craV8rWSlyRL8d9n8Lwd4dxNF0THbat7XHYRaN0UalKQwLLI-jCEGNAb55C09lwMAzMJNJszeTLTL7MJNL8F2n2KfrpdMZu02H9EjyZS8DnE2Cjs60PtndNPHOcScVkJRL39cg9Ny0eXn0BM1-spl7KZ8d8-hHcn_M2_EnvFFqaX6sbo5T4uQa2MmvxD_aOm-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67496970</pqid></control><display><type>article</type><title>Effect of an OT antagonist on the control of the midcycle LH surge in women</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Vanakara, P. ; Dafopoulos, K. ; Papastergiopoulou, L. ; Kallitsaris, A. ; Papageorgiou, I. ; Messinis, I. E.</creator><creatorcontrib>Vanakara, P. ; Dafopoulos, K. ; Papastergiopoulou, L. ; Kallitsaris, A. ; Papageorgiou, I. ; Messinis, I. E.</creatorcontrib><description>Summary
Objective Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re‐examined this matter in women with a fully characterized midcycle LH surge.
Design Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16–17 mm (Group 1) or 18–19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle‐1) or atosiban (cycle‐2).
Patients Fifteen women (10 in group 1 and 5 in group 2) aged 23–35 years.
Measurements Blood samples were obtained every 6 h to characterize the midcycle LH surge.
Results The time interval (mean ± SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46·8 ± 4·8 and 45·6 ± 9·6 h in group 1 and 6·0 ± 2·4 and 7·5 ± 2·8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle‐2 (41·2 ± 4·6 mIU/ml) was significantly lower than in cycle‐1 (52·8 ± 3·4 mIU/ml, P < 0·05). Nevertheless, in each group, the area under the curve for LH was similar in the two cycles.
Conclusions Antagonism of endogenous OT action by atosiban does not alter the LH profile during a fully characterized midcycle LH surge, suggesting that OT is not a major regulator of LH secretion in women.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2008.03456.x</identifier><identifier>PMID: 19178530</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone Antagonists - administration & dosage ; Humans ; Luteinizing Hormone - secretion ; Medical sciences ; Ovarian Follicle - drug effects ; Ovarian Follicle - secretion ; Oxytocin - antagonists & inhibitors ; Vasotocin - administration & dosage ; Vasotocin - analogs & derivatives ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Clinical endocrinology (Oxford), 2009-07, Vol.71 (1), p.100-103</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-ead48513062fe02ee72202c5bd0e450ca7fb2e5f372a4143b172ed6c8df96ad63</citedby><cites>FETCH-LOGICAL-c4356-ead48513062fe02ee72202c5bd0e450ca7fb2e5f372a4143b172ed6c8df96ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21561593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19178530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanakara, P.</creatorcontrib><creatorcontrib>Dafopoulos, K.</creatorcontrib><creatorcontrib>Papastergiopoulou, L.</creatorcontrib><creatorcontrib>Kallitsaris, A.</creatorcontrib><creatorcontrib>Papageorgiou, I.</creatorcontrib><creatorcontrib>Messinis, I. E.</creatorcontrib><title>Effect of an OT antagonist on the control of the midcycle LH surge in women</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re‐examined this matter in women with a fully characterized midcycle LH surge.
Design Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16–17 mm (Group 1) or 18–19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle‐1) or atosiban (cycle‐2).
Patients Fifteen women (10 in group 1 and 5 in group 2) aged 23–35 years.
Measurements Blood samples were obtained every 6 h to characterize the midcycle LH surge.
Results The time interval (mean ± SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46·8 ± 4·8 and 45·6 ± 9·6 h in group 1 and 6·0 ± 2·4 and 7·5 ± 2·8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle‐2 (41·2 ± 4·6 mIU/ml) was significantly lower than in cycle‐1 (52·8 ± 3·4 mIU/ml, P < 0·05). Nevertheless, in each group, the area under the curve for LH was similar in the two cycles.
Conclusions Antagonism of endogenous OT action by atosiban does not alter the LH profile during a fully characterized midcycle LH surge, suggesting that OT is not a major regulator of LH secretion in women.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone Antagonists - administration & dosage</subject><subject>Humans</subject><subject>Luteinizing Hormone - secretion</subject><subject>Medical sciences</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovarian Follicle - secretion</subject><subject>Oxytocin - antagonists & inhibitors</subject><subject>Vasotocin - administration & dosage</subject><subject>Vasotocin - analogs & derivatives</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkUtvEzEURi0EomnhLyBvYDfTa3tszyxYoCi0VaN0E2BpOZ7rMmEexZ6oyb_HQ6J0Wy_8PJ8fx4RQBjlL5XqbM6FkxrmSOQcocxCFVPn-DZmdF96SGQiADJQqLshljFsAkCXo9-SCVUyXUsCM3C-8RzfSwVPb04d1qkf7OPRNTHM9HX8jdUM_hqGdkGnYNbU7uBbp8pbGXXhE2vT0eeiw_0DeedtG_Hhqr8iP74v1_DZbPtzczb8tM1cIqTK0dVFKJkBxj8ARNefAndzUgIUEZ7XfcJReaG4LVogN0xxr5craV8rWSlyRL8d9n8Lwd4dxNF0THbat7XHYRaN0UalKQwLLI-jCEGNAb55C09lwMAzMJNJszeTLTL7MJNL8F2n2KfrpdMZu02H9EjyZS8DnE2Cjs60PtndNPHOcScVkJRL39cg9Ny0eXn0BM1-spl7KZ8d8-hHcn_M2_EnvFFqaX6sbo5T4uQa2MmvxD_aOm-g</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Vanakara, P.</creator><creator>Dafopoulos, K.</creator><creator>Papastergiopoulou, L.</creator><creator>Kallitsaris, A.</creator><creator>Papageorgiou, I.</creator><creator>Messinis, I. E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>Effect of an OT antagonist on the control of the midcycle LH surge in women</title><author>Vanakara, P. ; Dafopoulos, K. ; Papastergiopoulou, L. ; Kallitsaris, A. ; Papageorgiou, I. ; Messinis, I. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-ead48513062fe02ee72202c5bd0e450ca7fb2e5f372a4143b172ed6c8df96ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone Antagonists - administration & dosage</topic><topic>Humans</topic><topic>Luteinizing Hormone - secretion</topic><topic>Medical sciences</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovarian Follicle - secretion</topic><topic>Oxytocin - antagonists & inhibitors</topic><topic>Vasotocin - administration & dosage</topic><topic>Vasotocin - analogs & derivatives</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanakara, P.</creatorcontrib><creatorcontrib>Dafopoulos, K.</creatorcontrib><creatorcontrib>Papastergiopoulou, L.</creatorcontrib><creatorcontrib>Kallitsaris, A.</creatorcontrib><creatorcontrib>Papageorgiou, I.</creatorcontrib><creatorcontrib>Messinis, I. E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanakara, P.</au><au>Dafopoulos, K.</au><au>Papastergiopoulou, L.</au><au>Kallitsaris, A.</au><au>Papageorgiou, I.</au><au>Messinis, I. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of an OT antagonist on the control of the midcycle LH surge in women</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2009-07</date><risdate>2009</risdate><volume>71</volume><issue>1</issue><spage>100</spage><epage>103</epage><pages>100-103</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re‐examined this matter in women with a fully characterized midcycle LH surge.
Design Normal women were studied over two cycles. When the dominant follicle reached a diameter of either 16–17 mm (Group 1) or 18–19 mm (Group 2), the women were infused intravenously for 3 h with normal saline (cycle‐1) or atosiban (cycle‐2).
Patients Fifteen women (10 in group 1 and 5 in group 2) aged 23–35 years.
Measurements Blood samples were obtained every 6 h to characterize the midcycle LH surge.
Results The time interval (mean ± SEM) from the start of the infusion to the onset of the LH surge in the two cycles was 46·8 ± 4·8 and 45·6 ± 9·6 h in group 1 and 6·0 ± 2·4 and 7·5 ± 2·8 h, respectively, in group 2. LH values during the LH surge were similar in the two cycles except in group 1 at the point of 30 h at which LH value in cycle‐2 (41·2 ± 4·6 mIU/ml) was significantly lower than in cycle‐1 (52·8 ± 3·4 mIU/ml, P < 0·05). Nevertheless, in each group, the area under the curve for LH was similar in the two cycles.
Conclusions Antagonism of endogenous OT action by atosiban does not alter the LH profile during a fully characterized midcycle LH surge, suggesting that OT is not a major regulator of LH secretion in women.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19178530</pmid><doi>10.1111/j.1365-2265.2008.03456.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Endocrinopathies Female Fundamental and applied biological sciences. Psychology Hormone Antagonists - administration & dosage Humans Luteinizing Hormone - secretion Medical sciences Ovarian Follicle - drug effects Ovarian Follicle - secretion Oxytocin - antagonists & inhibitors Vasotocin - administration & dosage Vasotocin - analogs & derivatives Vertebrates: endocrinology Young Adult |
| title | Effect of an OT antagonist on the control of the midcycle LH surge in women |
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