Turning cells red: signal transduction mediated by erythropoietin

Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has been significant interest in understanding the unique ability of this ligand–receptor pair to promote erythroi...

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Bibliographic Details
Published in:Trends in cell biology 2005-03, Vol.15 (3), p.146-155
Main Authors: Richmond, Terri D., Chohan, Manprit, Barber, Dwayne L.
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Cell Differentiation
Cell Lineage
Cell Survival
Erythropoiesis - physiology
Erythropoietin - metabolism
Erythropoietin - physiology
Humans
Janus Kinase 2
Ligands
Mice
Models, Biological
Phosphatidylinositol 3-Kinases - metabolism
Phosphorylation
Protein Structure, Tertiary
Protein-Tyrosine Kinases - physiology
Proto-Oncogene Proteins - physiology
Proto-Oncogene Proteins c-bcl-2 - metabolism
Receptors, Erythropoietin - physiology
Signal Transduction
src Homology Domains
Tyrosine - chemistry
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Summary:Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has been significant interest in understanding the unique ability of this ligand–receptor pair to promote erythroid mitogenesis, survival and differentiation. The development of knockout mice has elucidated the precise role of the ligand, receptor and downstream players in murine erythroid development. In this review, we summarize EPO-mediated signaling pathways and examine their significance in vivo.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2005.01.007