Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β-Unsaturated Aldehydes

Symmetric fluoromethylation made easy: A highly enantioselective fluoromethyl addition to α,β‐unsaturated aldehydes is described (see scheme). The synthesis of chiral fluorinated blocks, including δ‐fluoro‐β‐aminoalcohol derivatives is disclosed.

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Bibliographic Details
Published in:Chemistry : a European journal 2009-07, Vol.15 (29), p.7035-7038
Main Authors: Alba, Andrea-Nekane, Companyó, Xavier, Moyano, Albert, Rios, Ramon
Format: Article
Language:English
Subjects:
Aldehydes - chemical synthesis
Aldehydes - chemistry
Anions - chemistry
Catalysis
enantioselectivity
fluorine
Hydrocarbons, Fluorinated - chemical synthesis
Hydrocarbons, Fluorinated - chemistry
nucleophilic addition
organocatalysis
Stereoisomerism
stereoselectivity
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Description
Summary:Symmetric fluoromethylation made easy: A highly enantioselective fluoromethyl addition to α,β‐unsaturated aldehydes is described (see scheme). The synthesis of chiral fluorinated blocks, including δ‐fluoro‐β‐aminoalcohol derivatives is disclosed.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200900991