Lithium inhibits brown adipocyte differentiation

Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 2005-03, Vol.579 (7), p.1670-1674
Main Authors: Rodrı́guez de la Concepción, Maria Luisa, Yubero, Pilar, Iglesias, Roser, Giralt, Marta, Villarroya, Francesc
Format: Article
Language:English
Subjects:
Adipocytes - cytology
Adipocytes - drug effects
Adipose Tissue, Brown - cytology
Adipose Tissue, Brown - drug effects
Animals
Biomarkers - analysis
Biomarkers - metabolism
Brown adipocyte
Carrier Proteins - genetics
Cell Differentiation - drug effects
Cell Differentiation - genetics
Cells, Cultured
cytochrome c oxidase
Down-Regulation
Gene Expression - drug effects
Ion Channels
Lithium
Lithium - pharmacology
Membrane Proteins - genetics
Mice
Mitochondrial Proteins
Mitochondrion
Norepinephrine - pharmacology
peroxisome proliferating activated receptor
PGC-1α
PPAR
PPAR gamma coactivator-1α
RNA, Messenger - analysis
RNA, Messenger - metabolism
Tretinoin - pharmacology
UCP-1
Uncoupling protein
Uncoupling Protein 1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation. Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor γ], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1α, and peroxisome proliferating activated receptor α, are particularly sensitive to lithium treatment-dependent downregulation. Brown adipocytes appear as preferential targets of the inhibitory action of lithium on adipocyte differentiation.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2005.02.021