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Lithium inhibits brown adipocyte differentiation
Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of...
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Published in: | FEBS letters 2005-03, Vol.579 (7), p.1670-1674 |
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container_title | FEBS letters |
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creator | Rodrı́guez de la Concepción, Maria Luisa Yubero, Pilar Iglesias, Roser Giralt, Marta Villarroya, Francesc |
description | Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation. Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor γ], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1α, and peroxisome proliferating activated receptor α, are particularly sensitive to lithium treatment-dependent downregulation. Brown adipocytes appear as preferential targets of the inhibitory action of lithium on adipocyte differentiation. |
doi_str_mv | 10.1016/j.febslet.2005.02.021 |
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These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation. Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor γ], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1α, and peroxisome proliferating activated receptor α, are particularly sensitive to lithium treatment-dependent downregulation. 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These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation. Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor γ], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1α, and peroxisome proliferating activated receptor α, are particularly sensitive to lithium treatment-dependent downregulation. Brown adipocytes appear as preferential targets of the inhibitory action of lithium on adipocyte differentiation.</description><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipose Tissue, Brown - cytology</subject><subject>Adipose Tissue, Brown - drug effects</subject><subject>Animals</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - metabolism</subject><subject>Brown adipocyte</subject><subject>Carrier Proteins - genetics</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - genetics</subject><subject>Cells, Cultured</subject><subject>cytochrome c oxidase</subject><subject>Down-Regulation</subject><subject>Gene Expression - drug effects</subject><subject>Ion Channels</subject><subject>Lithium</subject><subject>Lithium - pharmacology</subject><subject>Membrane Proteins - genetics</subject><subject>Mice</subject><subject>Mitochondrial Proteins</subject><subject>Mitochondrion</subject><subject>Norepinephrine - pharmacology</subject><subject>peroxisome proliferating activated receptor</subject><subject>PGC-1α</subject><subject>PPAR</subject><subject>PPAR gamma coactivator-1α</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - metabolism</subject><subject>Tretinoin - pharmacology</subject><subject>UCP-1</subject><subject>Uncoupling protein</subject><subject>Uncoupling Protein 1</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkM1LAzEQxYMoWj_-BKUnb1sn2U2yOYkWv6DgQYXeQpKd0JTtbk22Sv97d2nBo8LAMPDem8ePkEsKEwpU3CwnHm2qsZswAD4B1g89ICNayjzLC1EekhEALTIuVX5CTlNaQn-XVB2TE8oll4KrEYFZ6BZhsxqHZhFs6NLYxva7GZsqrFu37XBcBe8xYtMF04W2OSdH3tQJL_b7jHw8PrxPn7PZ69PL9G6WuULyeVZyAUMVmXPlK-WNAIuo0DErLGPCSMupdB5UDhXNS1tZYbAsvJLK0cLkZ-R6l7uO7ecGU6dXITmsa9Ngu0laSA6UAuuFfCd0sU0potfrGFYmbjUFPaDSS71HpQdUGlg_tPdd7R9s7AqrX9eeTS943gm-Q43b_6Xqx4d79jZwH7ADB2CMzfuo210U9sS-AkadXMDGYRUiuk5Xbfij7Q8RWpIo</recordid><startdate>20050314</startdate><enddate>20050314</enddate><creator>Rodrı́guez de la Concepción, Maria Luisa</creator><creator>Yubero, Pilar</creator><creator>Iglesias, Roser</creator><creator>Giralt, Marta</creator><creator>Villarroya, Francesc</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050314</creationdate><title>Lithium inhibits brown adipocyte differentiation</title><author>Rodrı́guez de la Concepción, Maria Luisa ; Yubero, Pilar ; Iglesias, Roser ; Giralt, Marta ; Villarroya, Francesc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475X-856018737359fd9fa60bee9ec2b6b226a7b517cf0930d138bdb6ae84f979c14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipose Tissue, Brown - cytology</topic><topic>Adipose Tissue, Brown - drug effects</topic><topic>Animals</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - metabolism</topic><topic>Brown adipocyte</topic><topic>Carrier Proteins - genetics</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - genetics</topic><topic>Cells, Cultured</topic><topic>cytochrome c oxidase</topic><topic>Down-Regulation</topic><topic>Gene Expression - drug effects</topic><topic>Ion Channels</topic><topic>Lithium</topic><topic>Lithium - pharmacology</topic><topic>Membrane Proteins - genetics</topic><topic>Mice</topic><topic>Mitochondrial Proteins</topic><topic>Mitochondrion</topic><topic>Norepinephrine - pharmacology</topic><topic>peroxisome proliferating activated receptor</topic><topic>PGC-1α</topic><topic>PPAR</topic><topic>PPAR gamma coactivator-1α</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - metabolism</topic><topic>Tretinoin - pharmacology</topic><topic>UCP-1</topic><topic>Uncoupling protein</topic><topic>Uncoupling Protein 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrı́guez de la Concepción, Maria Luisa</creatorcontrib><creatorcontrib>Yubero, Pilar</creatorcontrib><creatorcontrib>Iglesias, Roser</creatorcontrib><creatorcontrib>Giralt, Marta</creatorcontrib><creatorcontrib>Villarroya, Francesc</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrı́guez de la Concepción, Maria Luisa</au><au>Yubero, Pilar</au><au>Iglesias, Roser</au><au>Giralt, Marta</au><au>Villarroya, Francesc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithium inhibits brown adipocyte differentiation</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2005-03-14</date><risdate>2005</risdate><volume>579</volume><issue>7</issue><spage>1670</spage><epage>1674</epage><pages>1670-1674</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation. Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor γ], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1α, and peroxisome proliferating activated receptor α, are particularly sensitive to lithium treatment-dependent downregulation. Brown adipocytes appear as preferential targets of the inhibitory action of lithium on adipocyte differentiation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>15757659</pmid><doi>10.1016/j.febslet.2005.02.021</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adipocytes - cytology Adipocytes - drug effects Adipose Tissue, Brown - cytology Adipose Tissue, Brown - drug effects Animals Biomarkers - analysis Biomarkers - metabolism Brown adipocyte Carrier Proteins - genetics Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured cytochrome c oxidase Down-Regulation Gene Expression - drug effects Ion Channels Lithium Lithium - pharmacology Membrane Proteins - genetics Mice Mitochondrial Proteins Mitochondrion Norepinephrine - pharmacology peroxisome proliferating activated receptor PGC-1α PPAR PPAR gamma coactivator-1α RNA, Messenger - analysis RNA, Messenger - metabolism Tretinoin - pharmacology UCP-1 Uncoupling protein Uncoupling Protein 1 |
title | Lithium inhibits brown adipocyte differentiation |
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