Studies of Very Severe Short Stature with Severe GH Deficiency: From the Data Registered with the Foundation for Growth Science

• Published in: Endocrine Journal 2005, Vol.52(1), pp.37-43
• Main Authors: HANEW, Kunihiko, TACHIBANA, Katsuhiko, YOKOYA, Susumu, FUJIEDA, Kenji, TANAKA, Toshiaki, IGARASHI, Yutaka, SHIMATSU, Akira, TANAKA, Hiroyuki, TANIZAWA, Takakuni, TERAMOTO, Akira, NISHI, Yoshikazu, HASEGAWA, Yukihiro, HIZUKA, Naomi, HIRANO, Takeki, FUJITA, Keinosuke
• Format: Article
• Language: English
• Subjects: Age Determination by Skeleton; Asphyxia Neonatorum - epidemiology; Birth Weight; Body Height - drug effects; Child; Female; Gestational Age; Growth Disorders - blood; Growth Disorders - pathology; Growth Disorders - physiopathology; Human Growth Hormone - deficiency; Human Growth Hormone - therapeutic use; Humans; Idiopathic GHD; Incidence; Infant, Newborn; Insulin-Like Growth Factor I - metabolism; Male; Registries; Severe GHD; Severe short stature; Severity of Illness Index
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.52.37

The ratio, clinical characteristics, and therapeutic efficacy of hGH treatment in patients with severe short stature (HtSDS below –4SD) with severe GHD (all peak GH values to provocation tests: below 2 μg/L) were studied. From March 1986 to January 1998, 23,110 patients with idiopathic GH deficiency (IGHD) were registered with the Foundation for Growth Science, Japan. These subjects were divided into 5 groups as follows: Group 1 (G1), all subjects; Group 2 (G2), at least one GH peak to provocative test ≥5 μg/L; Group 3 (G3), 2 μg/L ≤GH peak