Humoral and cell-mediated immune responses in DNA immunized mink challenged with wild-type canine distemper virus

Abstract The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distem...

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Bibliographic Details
Published in:Vaccine 2009-07, Vol.27 (35), p.4791-4797
Main Authors: Nielsen, Line, Søgaard, Mette, Karlskov-Mortensen, Peter, Jensen, Trine Hammer, Jensen, Tove Dannemann, Aasted, Bent, Blixenkrone-Møller, Merete
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Viral - blood
Applied microbiology
Biological and medical sciences
Canine distemper virus
Cerebellum - virology
Cerebrum - virology
Deoxyribonucleic acid
Distemper - immunology
Distemper - prevention & control
Distemper Virus, Canine - genetics
Distemper Virus, Canine - immunology
DNA
DNA vaccination
Dogs
Fundamental and applied biological sciences. Psychology
Hemagglutinins, Viral - genetics
Hemagglutinins, Viral - immunology
Immune response
Immunity
Immunization
Infections
Injections
Interferon-gamma - secretion
Lung - virology
Lymphocytes
Lymphopenia - prevention & control
Microbiology
Mink
Miscellaneous
Nucleoproteins - genetics
Nucleoproteins - immunology
Plasmids
Spleen - virology
T-Lymphocytes - immunology
Urinary Bladder - virology
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - genetics
Vaccines, DNA - immunology
Viral Structural Proteins - genetics
Viral Structural Proteins - immunology
Viremia - prevention & control
Virology
Wildlife
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Summary:Abstract The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of CDV creates a constant viral reservoir among wildlife animals. Our results demonstrated early humoral and cell-mediated immune responses (IFN-gamma) in DNA vaccinated mink compared to mock-vaccinated mink after challenge with a Danish wild-type CDV. The DNA vaccine-induced immunity protected the natural host against disease development.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.05.090