Rephrasing anaphase: separase FEARs shugoshin

Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-pr...

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Bibliographic Details
Published in:Chromosoma 2005-03, Vol.113 (8), p.409-417
Main Authors: Stemmann, Olaf, Boos, Dominik, Gorr, Ingo H
Format: Article
Language:English
Subjects:
Anaphase - physiology
Animals
Cell Cycle Proteins - physiology
Cell division
Chromatids - physiology
Cytoskeletal Proteins - physiology
Endopeptidases - physiology
Humans
Phosphorylation
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - physiology
Separase
SUMO-1 Protein - physiology
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Summary:Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent linkage of sister chromatids.
ISSN:0009-5915
1432-0886
DOI:10.1007/s00412-005-0331-y