Effects of intravenous and inhaled levosimendan in severe rodent sepsis

Purpose We aimed at comparing the effects of intravenous (i.v.) and inhaled (inh.) levosimendan (LEVO) on survival, inflammatory cytokines and the apoptotic mediator caspase-3 in a rat model of severe sepsis induced by cecal ligation and incision (CLI). Methods Twenty-eight anesthetized/ventilated m...

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Bibliographic Details
Published in:Intensive care medicine 2009-08, Vol.35 (8), p.1412-1419
Main Authors: Scheiermann, Patrick, Ahluwalia, Devan, Hoegl, Sandra, Dolfen, Andrea, Revermann, Marc, Zwissler, Bernhard, Muhl, Heiko, Boost, Kim A., Hofstetter, Christian
Format: Article
Language:English
Subjects:
Administration, Inhalation
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Animals
Biological and medical sciences
Critical Care Medicine
Emergency and intensive care: infection, septic shock
Emergency Medicine
Humans
Hydrazones - administration & dosage
Hydrazones - pharmacology
Injections, Intraventricular
Intensive
Intensive care medicine
Medical sciences
Medicine
Medicine & Public Health
Models, Animal
Original
Pain Medicine
Pediatrics
Phosphodiesterase Inhibitors - administration & dosage
Phosphodiesterase Inhibitors - pharmacology
Pneumology/Respiratory System
Pyridazines - administration & dosage
Pyridazines - pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
Rodentia
Sepsis - diagnosis
Sepsis - drug therapy
Sepsis - etiology
Severity of Illness Index
Survival Analysis
Treatment Outcome
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Summary:Purpose We aimed at comparing the effects of intravenous (i.v.) and inhaled (inh.) levosimendan (LEVO) on survival, inflammatory cytokines and the apoptotic mediator caspase-3 in a rat model of severe sepsis induced by cecal ligation and incision (CLI). Methods Twenty-eight anesthetized/ventilated male Sprague–Dawley rats (body weight 528 ± 20 g) underwent laparotomy. Cecal mobilisation served as control (SHAM, n  = 7). In all other groups, severe sepsis was induced by CLI. No further intervention occurred in the CLI-group ( n  = 7). 180 min after CLI, 24 μg/kg i.v. LEVO was administered in the CLI + LEVO-IV-group ( n  = 7), and 24 μg/kg inh. LEVO was administered via jet nebulizer in the CLI + LEVO-INH-group ( n  = 7). Results CLI induced arterial hypotension, with i.v. and inh. LEVO attenuating blood pressure decrease over 390 min [CLI 34(31/50), CLI  +  LEVO-IV 82(69/131)*, CLI + LEVO-INH 78(62/85)* mmHg; median(25/75% quartile), * P  
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-009-1481-9