Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains

Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2005-03, Vol.52 (3), p.480-490
Main Authors: Yang, Marjorie U., Yaroslavsky, Anna N., Farinelli, William A., Flotte, Thomas J., Rius-Diaz, Francisca, Tsao, Sandy S., Anderson, R. Rox
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Dermatology
Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue
Humans
Laser Therapy
Medical sciences
Middle Aged
Pilot Projects
Port-Wine Stain - pathology
Port-Wine Stain - radiotherapy
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Summary:Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs. MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm 2. Purpura lasted longer after PDL. Treatment achieved similar 50% to 75% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery. Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2004.10.876