Myocardial injury occurs earlier than myocardial inflammation in acute experimental viral myocarditis

Endomyocardial biopsy often fails to show myocardial inflammation for patients with clinically suspected myocarditis. The serum isoforms of troponin T (cTnT) level is a very sensitive marker of myocardial injury and it is elevated even in the absence of myocardial inflammation. We investigated the c...

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Bibliographic Details
Published in:Experimental & molecular medicine 2005-02, Vol.37 (1), p.51-57
Main Authors: Lim, Byung-Kwan, Shin, Jae-Ok, Choe, Seong-Choon, Choi, Si-Wan, Jeong, Jin-Ok, Seong, In-Whan, Kim, Duk-Kyung, Jeon, Eun-Seok
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Coxsackievirus Infections - pathology
Enterovirus
Enterovirus B, Human - isolation & purification
Enterovirus B, Human - pathogenicity
Enterovirus B, Human - physiology
Female
Heart - virology
HeLa Cells
Humans
Inflammation - immunology
Mice
Mice, Inbred BALB C
Myocardial Infarction - immunology
Myocardial Infarction - pathology
Myocarditis - immunology
Myocarditis - pathology
Myocarditis - virology
Myocardium - immunology
Myocardium - pathology
Picornaviridae
Troponin T - blood
Virus Replication
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Summary:Endomyocardial biopsy often fails to show myocardial inflammation for patients with clinically suspected myocarditis. The serum isoforms of troponin T (cTnT) level is a very sensitive marker of myocardial injury and it is elevated even in the absence of myocardial inflammation. We investigated the correlations for myocardial injury, virus titers and inflammation in acute viral infection. Using the murine coxsackievirus group B3 (CVB3) myocarditis model, the histopathologic findings and virus titers in mouse hearts were compared with the serum cTnT levels measured by ELISA at various time points. Viable virus titers in the hearts peaked at 3 days after infection (8.22 +/- 0.13 log10 PFU/100 mg of heart); they decreased at day 7 and no viable virus was detected from day 14. Myocardial inflammation was minimal at day 3, peaked at day 7 and markedly decreased at day 14. The individual serum TnT levels were significantly increased at day 3 (7.37 +/- 1.46 ng/ml), persisted to day 7 (0.73 +/- 0.08 ng/ml), and normalized at day 14. Serum cTnT levels were correlatable with virus titers in the heart (r = 0.744, P
ISSN:1226-3613
2092-6413
2092-6413
DOI:10.1038/emm.2005.7