Characterization of an F18 + enterotoxigenic Escherichia coli strain from post weaning diarrhoea of swine, and of its conjugative virulence plasmid pTC

The enterotoxigenic Escherichia coli (ETEC) strain Ec2173, causing post weaning diarrhoea in swine, harbours six plasmids ranging from 13 to 200 kb in size. The heat stable toxin genes sta, stb and a tetracycline resistance gene were located on a self conjugative 120-kb plasmid, called pTC. In the c...

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Bibliographic Details
Published in:FEMS microbiology letters 2005-03, Vol.244 (2), p.281-289
Main Authors: Olasz, Ferenc, Fekete, Péter Zsolt, Blum-Oehler, Gabriele, Boldogkői, Zsolt, Nagy, Béla
Format: Article
Language:English
Subjects:
animal pathogenic bacteria
Animals
Antibiotics
Bacteria
Bacteriology
Biological and medical sciences
Clonal deletion
Conjugation, Genetic
Diarrhea
Diarrhea - microbiology
Diarrhea - veterinary
E coli
enterotoxigenic Escherichia coli
Enterotoxins - genetics
Epidemiology
Escherichia coli
Escherichia coli - classification
Escherichia coli - genetics
Escherichia coli - pathogenicity
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Escherichia coli Infections - veterinary
ETEC
Fimbriae, Bacterial - genetics
Fluorine Radioisotopes
Fundamental and applied biological sciences. Psychology
Genetics
Heat stable toxin gene
Maintenance of plasmids
Microbiology
Origin of replication
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
piglets
Plasmids
Plasmids - classification
Plasmids - genetics
Replication
Replication Origin
Replication origins
Swine
Swine Diseases - metabolism
Swine Diseases - microbiology
Tetracycline
Tetracycline - pharmacology
Toxins
Virulence
Virulence - genetics
Virulence plasmid
Weaning
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Summary:The enterotoxigenic Escherichia coli (ETEC) strain Ec2173, causing post weaning diarrhoea in swine, harbours six plasmids ranging from 13 to 200 kb in size. The heat stable toxin genes sta, stb and a tetracycline resistance gene were located on a self conjugative 120-kb plasmid, called pTC. In the cloned ColE1 type origin of replication of pTC a deletion was detected compared to other ColE1 replicons affecting the replication modulator gene rom. Epidemiological studies on ETEC isolates showed that pTC-like plasmids are widely distributed among porcine ETEC strains; thus representing an example of co-evolution of antibacterial resistance and virulence in pathogenic E. coli.
ISSN:0378-1097
1574-6968
DOI:10.1016/j.femsle.2005.01.057