Study of kinetic parameters in a mechanistic model for bioethanol production through a screening technique and optimization

The accurate description of the kinetics and robust modeling of biotechnological processes can only be achieved by incorporating reliable methodologies to easily update the model when there are changes in operational conditions. The purpose of this work is to provide a systematic approach with which...

Full description

Saved in:
Bibliographic Details
Published in:Bioprocess and biosystems engineering 2009-08, Vol.32 (5), p.673-680
Main Authors: de Andrade, Rafael Ramos, Rivera, Elmer Ccopa, Atala, Daniel I. P, Filho, Rubens Maciel, Filho, Francisco Maugeri, Costa, Aline C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bioreactors
Biotechnology
Carbohydrate Metabolism - physiology
Cell Proliferation
Chemistry
Chemistry and Materials Science
Computer Simulation
Environmental Engineering/Biotechnology
Ethanol - metabolism
Food Science
Fundamental and applied biological sciences. Psychology
Industrial and Production Engineering
Industrial Chemistry/Chemical Engineering
Kinetics
Methods. Procedures. Technologies
Models, Biological
Original Paper
Quality Control
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae - metabolism
Sugarcane
Various methods and equipments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The accurate description of the kinetics and robust modeling of biotechnological processes can only be achieved by incorporating reliable methodologies to easily update the model when there are changes in operational conditions. The purpose of this work is to provide a systematic approach with which to perform model parameters screening and updating in biotechnological processes. Batch experiments are performed to develop a mechanistic model, considering the effect of temperature on the kinetics, and further experiments (batch fermentations using sugar cane molasses from a different harvest) are used to validate the effectiveness of screening before parameters updating. The reduction in the number of kinetic parameters to be re-estimated enabled by the screening procedure reduces significantly the complexity of the optimization, which makes the updating procedure to be significantly quicker, while resulting in accurate performance of the updated model.
ISSN:1615-7591
1615-7605
DOI:10.1007/s00449-008-0291-8