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Study of kinetic parameters in a mechanistic model for bioethanol production through a screening technique and optimization
The accurate description of the kinetics and robust modeling of biotechnological processes can only be achieved by incorporating reliable methodologies to easily update the model when there are changes in operational conditions. The purpose of this work is to provide a systematic approach with which...
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| Published in: | Bioprocess and biosystems engineering 2009-08, Vol.32 (5), p.673-680 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c491t-31b13a1c18a468cd051302b1766cdb71249180edd623d983dd8a8a9a2436d4343 |
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| cites | cdi_FETCH-LOGICAL-c491t-31b13a1c18a468cd051302b1766cdb71249180edd623d983dd8a8a9a2436d4343 |
| container_end_page | 680 |
| container_issue | 5 |
| container_start_page | 673 |
| container_title | Bioprocess and biosystems engineering |
| container_volume | 32 |
| creator | de Andrade, Rafael Ramos Rivera, Elmer Ccopa Atala, Daniel I. P Filho, Rubens Maciel Filho, Francisco Maugeri Costa, Aline C |
| description | The accurate description of the kinetics and robust modeling of biotechnological processes can only be achieved by incorporating reliable methodologies to easily update the model when there are changes in operational conditions. The purpose of this work is to provide a systematic approach with which to perform model parameters screening and updating in biotechnological processes. Batch experiments are performed to develop a mechanistic model, considering the effect of temperature on the kinetics, and further experiments (batch fermentations using sugar cane molasses from a different harvest) are used to validate the effectiveness of screening before parameters updating. The reduction in the number of kinetic parameters to be re-estimated enabled by the screening procedure reduces significantly the complexity of the optimization, which makes the updating procedure to be significantly quicker, while resulting in accurate performance of the updated model. |
| doi_str_mv | 10.1007/s00449-008-0291-8 |
| format | article |
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| identifier | ISSN: 1615-7591 |
| ispartof | Bioprocess and biosystems engineering, 2009-08, Vol.32 (5), p.673-680 |
| issn | 1615-7591 1615-7605 |
| language | eng |
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| source | Springer Nature |
| subjects | Biological and medical sciences Bioreactors Biotechnology Carbohydrate Metabolism - physiology Cell Proliferation Chemistry Chemistry and Materials Science Computer Simulation Environmental Engineering/Biotechnology Ethanol - metabolism Food Science Fundamental and applied biological sciences. Psychology Industrial and Production Engineering Industrial Chemistry/Chemical Engineering Kinetics Methods. Procedures. Technologies Models, Biological Original Paper Quality Control Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Sugarcane Various methods and equipments |
| title | Study of kinetic parameters in a mechanistic model for bioethanol production through a screening technique and optimization |
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