Dietary lipids modulate eicosanoid release and apoptosis of cells of a murine lung alveolar carcinoma

Dietary arachidonic acid (AA) and eicosanoids influence neoplastic cell (NC) growth, differentiation and apoptosis. Plasma membrane fatty acid and cyclooxygenase (COX) and lipoxygenase (LOX) products were investigated in lung alveolar carcinoma cells from mice fed on different diets. Two groups were...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2005-04, Vol.72 (4), p.235-240
Main Authors: Pasqualini, M.E., Berra, M.A., Calderón, R.O., Cremonezzi, D.C., Giraudo, C., Eynard, A.R.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Bronchiolo-Alveolar - enzymology
Adenocarcinoma, Bronchiolo-Alveolar - pathology
Adenocarcinoma, Bronchiolo-Alveolar - secretion
Animals
Apoptosis - drug effects
Biological and medical sciences
Cell Membrane - metabolism
Dietary Fats - pharmacology
Eicosanoids - metabolism
Eicosanoids - secretion
Fatty Acids - metabolism
Female
Fundamental and applied biological sciences. Psychology
Lipoxygenase - metabolism
Medical sciences
Mice
Mice, Inbred BALB C
Pneumology
Prostaglandin-Endoperoxide Synthases - metabolism
Tumors of the respiratory system and mediastinum
Vertebrates: endocrinology
Xenograft Model Antitumor Assays
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Summary:Dietary arachidonic acid (AA) and eicosanoids influence neoplastic cell (NC) growth, differentiation and apoptosis. Plasma membrane fatty acid and cyclooxygenase (COX) and lipoxygenase (LOX) products were investigated in lung alveolar carcinoma cells from mice fed on different diets. Two groups were fed on a basic diet plus 6% of: corn oil (rich in 18:2n-6; CO) and on olein oil (rich in 18:1n-9; O), respectively. Control group (C) received commercial diet. NC fatty acids were analyzed by GLC, and apoptosis by flow cytometry and microscopy. In NC from CO group AA levels and LOX metabolites were increased, whereas COX metabolites decreased. NC from CO compared to O group diet showed a higher count of apoptosis and increased LOX:COX ratio. High levels of AA and decreased COX eicosanoids has been involved in anti-tumoral mechanisms by increasing tumor cell apoptosis. Present data emphasizes the implications of the dietary fatty acids on the neoplastic process in this tumoral model.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2004.11.002