HLA-B1832, a novel B allele was found through high-resolution HLA typing of a Spanish blood donor

In this paper, we describe the novel human leukocyte antigen (HLA)‐B*1832 allele that we found in a female Spanish volunteer blood donor for clinical investigation during her high‐resolution HLA typing. The HLA‐B typing is B*1801, 1832, and the DNA sequence is homozygous with the exception character...

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Bibliographic Details
Published in:Tissue antigens 2009-08, Vol.74 (2), p.170-172
Main Authors: Witter, K., Conrad, H., Bernhard, H., Albert, T., Kauke, T.
Format: Article
Language:English
Subjects:
Alleles
Base Sequence
Blood Donors
Female
high-resolution human leukocyte antigen typing
Histocompatibility Testing - methods
HLA-B Antigens - genetics
HLA-B1832
Humans
Mass Screening
Molecular Sequence Data
polymerase chain reaction
Polymorphism, Single Nucleotide
Sequence Homology, Nucleic Acid
Spain
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Summary:In this paper, we describe the novel human leukocyte antigen (HLA)‐B*1832 allele that we found in a female Spanish volunteer blood donor for clinical investigation during her high‐resolution HLA typing. The HLA‐B typing is B*1801, 1832, and the DNA sequence is homozygous with the exception characterized by a nucleotide exchange ‘C’ to ‘A’ at position 505, which, in consequence, replaced arginine at codon 169 (CGC) by serine in the new allele B*1832.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2009.01268.x