Leptin receptor action and mechanisms of leptin resistance

The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2005-03, Vol.62 (6), p.642-652, Article 642
Main Authors: Münzberg, H, Björnholm, M, Bates, S H, Myers, Jr, M G
Format: Article
Language:English
Subjects:
Adipose tissue
Animals
Cytokines
DNA-Binding Proteins - metabolism
Endocrinology
Energy balance
Energy Metabolism
Hormones
Humans
Hypothalamus - anatomy & histology
Hypothalamus - metabolism
Leptin - metabolism
Nerve Net - physiology
Obesity
Obesity - metabolism
Receptors, Cell Surface - metabolism
Receptors, Leptin
Signal Transduction - physiology
STAT3 Transcription Factor
Trans-Activators - metabolism
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Summary:The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-004-4432-1