Association of plasma cholesteryl ester transfer protein activity and polymorphism with coronary artery disease extent in Tunisian type II diabetic patients

Cholesteryl ester transfer protein (CETP), a key protein in reverse cholesterol transport, has a controversial role in atherosclerosis. We investigated CETP activity and polymorphism in Tunisian type II diabetes and its relationship with coronary artery disease (CAD). 173 type II diabetic patients w...

Full description

Saved in:
Bibliographic Details
Published in:Clinical biochemistry 2005-04, Vol.38 (4), p.373-378
Main Authors: Chaaba, R., Hammami, S., Attia, N., Smaoui, M., Masmoudi, A.S., Mahjoub, S., Ben Hamda, K., Hammami, M.
Format: Article
Language:English
Subjects:
Adult
CAD extent
Carrier Proteins - blood
Carrier Proteins - genetics
Carrier Proteins - physiology
Case-Control Studies
CETP activity
Cholesterol Ester Transfer Proteins
Cholesterol Esters
Cholesteryl ester transfer protein (CETP)
Coronary artery disease (CAD)
Coronary Artery Disease - blood
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Female
Glycoproteins - blood
Glycoproteins - genetics
Glycoproteins - physiology
HDL cholesterol
Humans
Male
Middle Aged
Polymorphism, Genetic
Taq IB polymorphism
Triglycerides
Tunisia - epidemiology
Tunisian
Type II diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cholesteryl ester transfer protein (CETP), a key protein in reverse cholesterol transport, has a controversial role in atherosclerosis. We investigated CETP activity and polymorphism in Tunisian type II diabetes and its relationship with coronary artery disease (CAD). 173 type II diabetic patients with or without CAD were compared to 67 controls. The HDL cholesterol concentration was low in a Tunisian population. The B1 allele of the CETP gene was associated with a low concentration of HDL cholesterol and was more frequent in Tunisians than in other populations. In type II diabetic patients, the B1 allele was associated with increased prevalence of CAD only in men (OR = 0.357, CI = 0.161–0.791, P = 0.01). The CETP activity increased in type II diabetic patients compared to controls ( P = 0.05). Furthermore, the CETP activity was increased in patients with double or triple vessel disease compared to those with single vessel disease ( P = 0.025). Our data are in favour of an association between CETP and developing CAD, as well as the extent of CAD.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2004.12.011