Hopane-type saponins from Glinus lotoides Linn

• Published in: Phytochemistry (Oxford) 2005-03, Vol.66 (6), p.621-626
• Main Authors: Biswas, Tanusree, Gupta, Moumita, Achari, Basudeb, Pal, Bikas C.
• Format: Article
• Language: English
• Subjects: Aizoaceae; Biological and medical sciences; Chemical constitution; chemical structure; Fundamental and applied biological sciences. Psychology; Glinus lotoides; hopane; Hopane-type saponins; lotoidesides; Lotoidesides A–F; medicinal plants; Molecular Structure; Molluginaceae - chemistry; Mollugo; Mollugo hirta; phytochemicals; plant extracts; Plant physiology and development; saponins; Saponins - chemistry; Saponins - isolation & purification; spectral analysis
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2005.02.012

Six hopane-type saponins, lotoidesides A–F, along with a known compound were isolated. Their structures were elucidated by 2D NMR analysis, mass spectrometry and chemical evidences. Seven hopane-type saponins were isolated from the methanol extract of Glinus lotoides. Six of them were identified as novel compounds and designated as lotoideside A [3- O-β- d-xylopyranosyl (1 → 2)-α- l-rhamnopyranosyl-6α- O-β- d-xylopyranosyl-22-β- O-β- d-glucopyranosyl-16β-hydroxy hopane ( 1)], lotoideside B [3- O-β- d-xylopyranosyl (1 → 2)-α- l-rhamnopyranosyl-22-β- O-β- d-glucopyranosyl-6α,16β-dihydroxyhopane ( 2)], lotoideside C [3- O d-xylopyranosyl-6α- O-β- d-xylopyranosyl-16β- O-β- d-xylopyranosyl-22β-hydroxyhopane ( 3)], lotoideside D [3- O-β- d-xylopyranosyl-16β- O-α- l-arabinopyranosyl-6α,22-β-dihydroxyhopane ( 4)], lotoideside E [3- O-β- d-xylopyranosyl-6α- O-β- d-xylopyranosyl-16 β,22-β-dihydroxyhopane ( 5)], and lotoideside F [3- O-β- d-xylopyranosyl-22-β- O-β- d-glucopyranosyl-16β-hydroxyhopan-6-one ( 6)]. The known compound succulentoside B ( 7) was also encountered. Their structures were elucidated on the basis of one-and two-dimensional NMR spectroscopic techniques, ESIMS and chemical evidences.