Lymphoid progenitors and primary routes to becoming cells of the immune system

Extraordinary progress has been made in charting the maturation of hematopoietic cells. However, these charted processes do not necessarily represent obligate pathways to specialized types of lymphocytes. In fact, there is a degree of plasticity associated with primitive progenitors. Moreover, all l...

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Bibliographic Details
Published in:Current opinion in immunology 2005-04, Vol.17 (2), p.100-107
Main Authors: Pelayo, Rosana, Welner, Rob, Perry, S Scott, Huang, Jiaxue, Baba, Yoshihiro, Yokota, Takafumi, Kincade, Paul W
Format: Article
Language:English
Subjects:
Animals
Bone Marrow - immunology
Bone Marrow - physiology
Cell Differentiation - physiology
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - physiology
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - immunology
Hematopoietic Stem Cells - physiology
Humans
Immune System - cytology
Immune System - immunology
Immune System - physiology
Lymphocytes - cytology
Lymphocytes - immunology
Lymphocytes - physiology
Proto-Oncogene Proteins c-kit - physiology
Thymus Gland - cytology
Thymus Gland - immunology
Thymus Gland - physiology
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Summary:Extraordinary progress has been made in charting the maturation of hematopoietic cells. However, these charted processes do not necessarily represent obligate pathways to specialized types of lymphocytes. In fact, there is a degree of plasticity associated with primitive progenitors. Moreover, all lymphocytes of a given kind are not necessarily produced through precisely the same sequence of events. Particularly contentious is the nature of cells that seed the thymus, because different progenitors can generate T cells under experimental circumstances. Non-renewing progenitors with a high density of c-Kit in bone marrow are likely to replenish the thymus under normal circumstances and most closely resemble canonical T cell progenitors.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2005.01.012