Intestinal immune activation in presumed post‐infectious functional dyspepsia

Functional dyspepsia (FD) symptoms may develop after an acute gastroenteritis. In post‐infectious (PI) irritable bowel syndrome, persisting low‐grade colonic inflammation and increased enterochromaffine cells (EC) counts have been reported. The aim was to compare signs of inflammation and EC hyperpl...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2009-08, Vol.21 (8), p.832-e56
Main Authors: Kindt, S., Tertychnyy, A., De Hertogh, G., Geboes, K., Tack, J.
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - immunology
Biopsy
cryptopatch
duodenum
Duodenum - cytology
Duodenum - immunology
Duodenum - pathology
Dyspepsia - etiology
Dyspepsia - immunology
Dyspepsia - physiopathology
Female
functional dyspepsia
Gastric Emptying - physiology
Gastroenteritis - complications
Gastroenteritis - immunology
Gastroenteritis - physiopathology
Humans
inflammation
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Intestinal Mucosa - pathology
Irritable Bowel Syndrome - etiology
Irritable Bowel Syndrome - immunology
Irritable Bowel Syndrome - physiopathology
lymphocytes
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - immunology
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:Functional dyspepsia (FD) symptoms may develop after an acute gastroenteritis. In post‐infectious (PI) irritable bowel syndrome, persisting low‐grade colonic inflammation and increased enterochromaffine cells (EC) counts have been reported. The aim was to compare signs of inflammation and EC hyperplasia on duodenal biopsies in presumed PI‐FD and unspecified‐onset (U‐)FD. Duodenal biopsies were obtained in 12 U‐FD and 12 PI‐FD (on average 13 months after the acute event) patients. The presence of intra‐epithelial, intravillar, and the number of CD3, CD4, CD8 and CD68+ cells per crypts, and the mean number of Chromogranine A (CA) positive cells per villus were compared. We also measured gastric emptying and assessed proximal stomach function with a barostat. Data are shown as mean ± SEM. Focal aggregates of T cells and focal CD8+ aggregates, were found in PI‐FD but not in U‐FD patients (respectively 5/12 vs 0/12, P = 0.02 and 5/9 vs 0/11, P 
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2009.01299.x