Ewing Sarcoma Demonstrates Racial Disparities in Incidence-related and Sex-related Differences in Outcome: An Analysis of 1631 Cases From the SEER Database, 1973-2005

Previous reports of Ewing sarcoma cohorts suggested that there is a difference in incidence according to racial origin. However, to the authors' knowledge, this finding has never been tested in a population-based database, and the impact of race on clinical outcome and the significance of known...

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Published in:Cancer 2009-08, Vol.115 (15), p.3526-3536
Main Authors: JAWAD, Muhammad U, CHEUNG, Michael C, MIN, Elijah S, SCHNEIDERBAUER, Michaela M, KONIARIS, Leonidas G, SCULLY, Sean P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Black or African American
Black People
Bone Neoplasms - epidemiology
Bone Neoplasms - ethnology
Bone Neoplasms - mortality
Child
Child, Preschool
Diseases of the osteoarticular system
Female
Hispanic or Latino
Humans
Incidence
Infant
Infant, Newborn
Medical sciences
Middle Aged
Prognosis
Racial Groups
Risk Factors
Sarcoma, Ewing - epidemiology
Sarcoma, Ewing - ethnology
Sarcoma, Ewing - mortality
SEER Program
Sex Distribution
Tumors
Tumors of striated muscle and skeleton
White People
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container_end_page 3536
container_issue 15
container_start_page 3526
container_title Cancer
container_volume 115
creator JAWAD, Muhammad U
CHEUNG, Michael C
MIN, Elijah S
SCHNEIDERBAUER, Michaela M
KONIARIS, Leonidas G
SCULLY, Sean P
description Previous reports of Ewing sarcoma cohorts suggested that there is a difference in incidence according to racial origin. However, to the authors' knowledge, this finding has never been tested in a population-based database, and the impact of race on clinical outcome and the significance of known risk factors stratified to racial groups have not been reported. Patients who had Ewing sarcoma diagnosed between 1973 and 2005 were identified in the Surveillance, Epidemiology, and End Results database. Patient demographic and clinical characteristics; incidence; year of diagnosis; tumor location, tumor size, and disease stage at diagnosis; treatment(s); cause of death; and survival were extracted. Kaplan-Meier, log-rank, and Cox regressions were used to analyze the significance of prognostic factors. Race-specific incidence indicated that Caucasians have the highest incidence (0.155), followed by Asians/Pacific Islanders (0.082), and African Americans (0.017). The difference in incidence between Caucasians and African Americans was 9-fold and significant (P
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However, to the authors' knowledge, this finding has never been tested in a population-based database, and the impact of race on clinical outcome and the significance of known risk factors stratified to racial groups have not been reported. Patients who had Ewing sarcoma diagnosed between 1973 and 2005 were identified in the Surveillance, Epidemiology, and End Results database. Patient demographic and clinical characteristics; incidence; year of diagnosis; tumor location, tumor size, and disease stage at diagnosis; treatment(s); cause of death; and survival were extracted. Kaplan-Meier, log-rank, and Cox regressions were used to analyze the significance of prognostic factors. Race-specific incidence indicated that Caucasians have the highest incidence (0.155), followed by Asians/Pacific Islanders (0.082), and African Americans (0.017). The difference in incidence between Caucasians and African Americans was 9-fold and significant (P&lt;.001). The incidence of Ewing sarcoma increased over the past 3 decades among Caucasians (P&lt;.05). Survival was not impacted by race. Local disease stage, primary tumor location in the appendicular skeleton, and tumor size&lt;or=8 cm conferred a significant survival benefit. Women demonstrated improved survival among the Caucasian patients (P&lt;.03). To the authors' knowledge, this is the first report focusing on racial disparity in incidence of Ewing sarcoma. Caucasians were affected more frequently, although outcomes were similar between races. It is noteworthy that being a woman constituted a survival benefit only among the Caucasian patients. 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However, to the authors' knowledge, this finding has never been tested in a population-based database, and the impact of race on clinical outcome and the significance of known risk factors stratified to racial groups have not been reported. Patients who had Ewing sarcoma diagnosed between 1973 and 2005 were identified in the Surveillance, Epidemiology, and End Results database. Patient demographic and clinical characteristics; incidence; year of diagnosis; tumor location, tumor size, and disease stage at diagnosis; treatment(s); cause of death; and survival were extracted. Kaplan-Meier, log-rank, and Cox regressions were used to analyze the significance of prognostic factors. Race-specific incidence indicated that Caucasians have the highest incidence (0.155), followed by Asians/Pacific Islanders (0.082), and African Americans (0.017). The difference in incidence between Caucasians and African Americans was 9-fold and significant (P&lt;.001). 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source Wiley-Blackwell Read & Publish Collection; Free E-Journal (出版社公開部分のみ）
subjects Adolescent
Adult
Biological and medical sciences
Black or African American
Black People
Bone Neoplasms - epidemiology
Bone Neoplasms - ethnology
Bone Neoplasms - mortality
Child
Child, Preschool
Diseases of the osteoarticular system
Female
Hispanic or Latino
Humans
Incidence
Infant
Infant, Newborn
Medical sciences
Middle Aged
Prognosis
Racial Groups
Risk Factors
Sarcoma, Ewing - epidemiology
Sarcoma, Ewing - ethnology
Sarcoma, Ewing - mortality
SEER Program
Sex Distribution
Tumors
Tumors of striated muscle and skeleton
White People
title Ewing Sarcoma Demonstrates Racial Disparities in Incidence-related and Sex-related Differences in Outcome: An Analysis of 1631 Cases From the SEER Database, 1973-2005
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