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Development and validation of an improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma
An improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma was developed and validated using a simple quadrupole LC–MS and a new SPE cartridge (Plexa ® Bond Elut). The analysis was achieved with a C18 analytical column using a mobile phase consisti...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2009-08, Vol.877 (24), p.2451-2456 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c453t-b15b5b34e57392043cd97fe7654e8b9720302c64487304b9ecf34438b74dbcc73 |
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| cites | cdi_FETCH-LOGICAL-c453t-b15b5b34e57392043cd97fe7654e8b9720302c64487304b9ecf34438b74dbcc73 |
| container_end_page | 2456 |
| container_issue | 24 |
| container_start_page | 2451 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 877 |
| creator | Bobin-Dubigeon, C. Amiand, M.B. Herrenknecht, C. Bard, J.M. |
| description | An improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma was developed and validated using a simple quadrupole LC–MS and a new SPE cartridge (Plexa
® Bond Elut). The analysis was achieved with a C18 analytical column using a mobile phase consisting of formic acid/acetonitrile and isocratic flow for 7
min. The linear ranges (
r
2
>
0.99) were found from 5 to 5000
ng/mL. The lower limit of detection was 2.5
ng/mL. Within-day and between-day precisions were less than 7.2% and inaccuracy did not exceed 2.8%. This new method is suitable to support pharmacokinetic studies and drug monitoring. |
| doi_str_mv | 10.1016/j.jchromb.2009.06.020 |
| format | article |
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® Bond Elut). The analysis was achieved with a C18 analytical column using a mobile phase consisting of formic acid/acetonitrile and isocratic flow for 7
min. The linear ranges (
r
2
>
0.99) were found from 5 to 5000
ng/mL. The lower limit of detection was 2.5
ng/mL. Within-day and between-day precisions were less than 7.2% and inaccuracy did not exceed 2.8%. This new method is suitable to support pharmacokinetic studies and drug monitoring.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2009.06.020</identifier><identifier>PMID: 19560408</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Antineoplastic Agents - blood ; Biological and medical sciences ; Chromatography, Liquid - methods ; Drug Monitoring - methods ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Glutamates - blood ; Guanine - analogs & derivatives ; Guanine - blood ; Humans ; Liquid chromatography/mass spectrometry ; Mass Spectrometry - methods ; Medical sciences ; Pemetrexed ; Pharmacokinetic studies ; Pharmacology. Drug treatments ; Plasma ; Sensitivity and Specificity</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-08, Vol.877 (24), p.2451-2456</ispartof><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-b15b5b34e57392043cd97fe7654e8b9720302c64487304b9ecf34438b74dbcc73</citedby><cites>FETCH-LOGICAL-c453t-b15b5b34e57392043cd97fe7654e8b9720302c64487304b9ecf34438b74dbcc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21789553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19560408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bobin-Dubigeon, C.</creatorcontrib><creatorcontrib>Amiand, M.B.</creatorcontrib><creatorcontrib>Herrenknecht, C.</creatorcontrib><creatorcontrib>Bard, J.M.</creatorcontrib><title>Development and validation of an improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>An improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma was developed and validated using a simple quadrupole LC–MS and a new SPE cartridge (Plexa
® Bond Elut). The analysis was achieved with a C18 analytical column using a mobile phase consisting of formic acid/acetonitrile and isocratic flow for 7
min. The linear ranges (
r
2
>
0.99) were found from 5 to 5000
ng/mL. The lower limit of detection was 2.5
ng/mL. Within-day and between-day precisions were less than 7.2% and inaccuracy did not exceed 2.8%. This new method is suitable to support pharmacokinetic studies and drug monitoring.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Antineoplastic Agents - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - methods</subject><subject>Drug Monitoring - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Glutamates - blood</subject><subject>Guanine - analogs & derivatives</subject><subject>Guanine - blood</subject><subject>Humans</subject><subject>Liquid chromatography/mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Pemetrexed</subject><subject>Pharmacokinetic studies</subject><subject>Pharmacology. 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Psychology</topic><topic>General pharmacology</topic><topic>Glutamates - blood</topic><topic>Guanine - analogs & derivatives</topic><topic>Guanine - blood</topic><topic>Humans</topic><topic>Liquid chromatography/mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Medical sciences</topic><topic>Pemetrexed</topic><topic>Pharmacokinetic studies</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasma</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bobin-Dubigeon, C.</creatorcontrib><creatorcontrib>Amiand, M.B.</creatorcontrib><creatorcontrib>Herrenknecht, C.</creatorcontrib><creatorcontrib>Bard, J.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2009-08-15</date><risdate>2009</risdate><volume>877</volume><issue>24</issue><spage>2451</spage><epage>2456</epage><pages>2451-2456</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>An improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma was developed and validated using a simple quadrupole LC–MS and a new SPE cartridge (Plexa
® Bond Elut). The analysis was achieved with a C18 analytical column using a mobile phase consisting of formic acid/acetonitrile and isocratic flow for 7
min. The linear ranges (
r
2
>
0.99) were found from 5 to 5000
ng/mL. The lower limit of detection was 2.5
ng/mL. Within-day and between-day precisions were less than 7.2% and inaccuracy did not exceed 2.8%. This new method is suitable to support pharmacokinetic studies and drug monitoring.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19560408</pmid><doi>10.1016/j.jchromb.2009.06.020</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-08, Vol.877 (24), p.2451-2456 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67524422 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Analysis Analytical, structural and metabolic biochemistry Antineoplastic Agents - blood Biological and medical sciences Chromatography, Liquid - methods Drug Monitoring - methods Fundamental and applied biological sciences. Psychology General pharmacology Glutamates - blood Guanine - analogs & derivatives Guanine - blood Humans Liquid chromatography/mass spectrometry Mass Spectrometry - methods Medical sciences Pemetrexed Pharmacokinetic studies Pharmacology. Drug treatments Plasma Sensitivity and Specificity |
| title | Development and validation of an improved liquid chromatography–mass spectrometry method for the determination of pemetrexed in human plasma |
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