The main stages in the history of systemic lupus erythematosus

Systemic lupus erythematosus can be considered the most characteristic and important among the connective tissue diseases. In this short review the main stages of its history are sketched, from the introduction of the term “lupus”, traditionally attributed to Roger Frugardi, in 1230 (but in fact alr...

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Bibliographic Details
Published in:Reumatismo 2009-06, Vol.61 (2), p.145-152
Main Authors: Rampudda, M, Marson, P, Pasero, G
Format: Article
Language:eng ; ita
Subjects:
Lupus
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Summary:Systemic lupus erythematosus can be considered the most characteristic and important among the connective tissue diseases. In this short review the main stages of its history are sketched, from the introduction of the term “lupus”, traditionally attributed to Roger Frugardi, in 1230 (but in fact already documented in the 10th century) to the actual knowledge of its clinical and laboratory aspects. Initially considered exclusively of dermatological interest, the first to describe a systemic form with visceral involvement were Moriz Kohn Kaposi and William Osler. Significant contribution was also given by serological diagnosis, and in particular, by the identification of specific markers of disease, such as anti-native DNA and anti-Sm antibodies, allowing early diagnosis and the establishment of an adequate therapy.
ISSN:0048-7449
2240-2683
DOI:10.4081/reumatismo.2009.145