Synthesis of 15R-PGD2 : a potential DP2 receptor agonist

The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2005-04, Vol.15 (7), p.1873-1876
Main Authors: KIM, Seongjin, BELLONE, Sophie, MAXEY, Kirk M, POWELL, William S, LEE, Gue-Jae, ROKACH, Joshua
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Platelets - drug effects
Blood Platelets - metabolism
Cyclic AMP - metabolism
Isomerism
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Prostaglandin D2 - analogs & derivatives
Prostaglandin D2 - chemical synthesis
Prostaglandin D2 - pharmacology
Receptors, Immunologic - agonists
Receptors, Immunologic - metabolism
Receptors, Prostaglandin - agonists
Receptors, Prostaglandin - metabolism
Structure-Activity Relationship
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Description
Summary:The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.02.011