Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses

: In addition to its role as an energy storage depot, adipose tissue is now recognized as a complex endocrine organ. Adipose tissue releases a variety of factors, termed adipokines, that regulate energy metabolism, cardiovascular function, reproductive status, and immune function. Some of the better...

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Bibliographic Details
Published in:Veterinary clinical pathology 2009-06, Vol.38 (2), p.136-156
Main Authors: Radin, M. Judith, Sharkey, Leslie C, Holycross, Bethany J
Format: Article
Language:English
Subjects:
Adipokines
Adipokines - metabolism
adiponectin
adipose tissue
Adipose Tissue - immunology
Adipose Tissue - physiology
angiotensinogen
animal physiology
animal reproduction
Animals
cardiovascular system
cats
Cats - physiology
dogs
Dogs - physiology
Energy Metabolism
exocrine glands
horses
Horses - physiology
immune system
leptin
literature reviews
Obesity
obesity-related diseases
renin
renin-angiotensin system
resistin
secretion
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Summary:: In addition to its role as an energy storage depot, adipose tissue is now recognized as a complex endocrine organ. Adipose tissue releases a variety of factors, termed adipokines, that regulate energy metabolism, cardiovascular function, reproductive status, and immune function. Some of the better‐studied adipokines include leptin, adiponectin, and components of the renin‐angiotensin system such as angiotensinogen. The function of more recently discovered adipokines such as resistin are under intense scrutiny. Abnormal production or regulation of adipokines occurs in obese individuals and is implicated in the development of a variety of associated co‐morbidities including metabolic syndrome, type 2 diabetes, atherosclerosis, heart disease, and cancer in people, although evaluation in domestic species is just beginning. Adipokines are now being examined as potential biomarkers for risk assessment for development of complications related to obesity. This article summarizes the function and regulation of some better‐characterized adipokines. It also reviews the current information on the characterization of adipokines in some domestic species in which rates of obesity and obesity‐related disorders are increasing, such as the dog, cat, and horse.
ISSN:0275-6382
1939-165X
DOI:10.1111/j.1939-165X.2009.00133.x