Comparison of cilostazol and clopidogrel after successful coronary stenting

This study compared the safety and efficacy of cilostazol and clopidogrel after coronary stenting. Patients (n = 689) who underwent successful stenting were randomly assigned to receive cilostazol (group 1, n = 344, 612 lesions) or clopidogrel (group 2, n = 345, 628 lesions). The incidence of subacu...

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Bibliographic Details
Published in:The American journal of cardiology 2005-04, Vol.95 (7), p.859-862
Main Authors: Lee, Seung-Whan, Park, Seong-Wook, Hong, Myeong-Ki, Lee, Cheol Whan, Kim, Young-Hak, Park, Jae-Hyeong, Kang, Su-Jin, Han, Ki-Hoon, Kim, Jae-Joong, Park, Seung-Jung
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon, Coronary - adverse effects
Aspirin - therapeutic use
Coronary Restenosis - etiology
Coronary Restenosis - prevention & control
Female
Humans
Male
Middle Aged
Myocardial Infarction - etiology
Myocardial Infarction - prevention & control
Platelet Aggregation Inhibitors - therapeutic use
Prospective Studies
Stents - adverse effects
Tetrazoles - therapeutic use
Thrombosis - etiology
Thrombosis - prevention & control
Ticlopidine - analogs & derivatives
Ticlopidine - therapeutic use
Treatment Outcome
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Summary:This study compared the safety and efficacy of cilostazol and clopidogrel after coronary stenting. Patients (n = 689) who underwent successful stenting were randomly assigned to receive cilostazol (group 1, n = 344, 612 lesions) or clopidogrel (group 2, n = 345, 628 lesions). The incidence of subacute stent thrombosis or major adverse cardiac events, including death, myocardial infarction, and target lesion revascularization within 30 days (2.6% in group 1 vs 2.0% in group 2, p = 0.61) and side effects that required cessation of study drug (0.6% each) did not differ statistically between groups. These results indicate that cilostazol is as safe and effective as clopidogrel in preventing thrombotic complications after stenting.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.12.012