Antioxidant defence during cardiopulmonary bypass surgery

Objective: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. Methods: At six time po...

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Bibliographic Details
Published in:European journal of cardio-thoracic surgery 2005-04, Vol.27 (4), p.611-616
Main Authors: Luyten, Chris R., van Overveld, Frans J., De Backer, Lieve A., Sadowska, Anna M., Rodrigus, Inez E., De Hert, Stefan G., De Backer, Wilfried A.
Format: Article
Language:English
Subjects:
Aged
Antioxidants
Antioxidants - metabolism
Biological and medical sciences
Biomarkers - blood
Bypass surgery
Cardiology. Vascular system
Cardiopulmonary Bypass
Coronary Artery Bypass
Eosinophil Cationic Protein - blood
Female
Glutathione peroxidase
Glutathione Peroxidase - blood
Humans
Intraoperative Period
Male
Medical sciences
Middle Aged
Oxidative Stress
Pneumology
Postoperative Period
Serine Endopeptidases - blood
Superoxide dismutase
Superoxide Dismutase - blood
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Tryptases
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Summary:Objective: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. Methods: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. Results: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30%, respectively), returning to baseline values 24h after surgery. The total antioxidant capacity has a maximum increase of 60%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. Conclusion: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage.
ISSN:1010-7940
1873-734X
DOI:10.1016/j.ejcts.2004.12.013