Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa

NGF is implicated in retinal damage regression. To study whether this is a direct effect or an effect mediated by NGF on other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration...

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Bibliographic Details
Published in:Vision research (Oxford) 2005-06, Vol.45 (12), p.1491-1500
Main Authors: Lenzi, Laura, Coassin, Marco, Lambiase, Alessandro, Bonini, Stefano, Amendola, Tiziana, Aloe, Luigi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain-Derived Neurotrophic Factor - analysis
Eye and associated structures. Visual pathways and centers. Vision
Eye Proteins - metabolism
Fibroblast Growth Factors - analysis
Fundamental and applied biological sciences. Psychology
Medical sciences
Needles
Nerve Growth Factor - immunology
Nerve Growth Factor - pharmacology
Neuropeptide Y - analysis
NGF
Ophthalmology
Photoreceptor Cells - drug effects
Rats
Rats, Inbred Strains
RCS rat
Receptor, trkA - analysis
Retina - drug effects
Retina - metabolism
Retinal dystrophy
Retinal Vessels - drug effects
Retinitis Pigmentosa - metabolism
Retinopathies
Transforming Growth Factor beta - analysis
Tumor Necrosis Factor-alpha - analysis
Vascular Endothelial Growth Factor A - analysis
VEGF
Vertebrates: nervous system and sense organs
β-FGF
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Summary:NGF is implicated in retinal damage regression. To study whether this is a direct effect or an effect mediated by NGF on other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration exerts a rescue effect on photoreceptors in this animal model. NGF injection enhances brain-derived neurotrophic factor, β-fibroblast growth factor, transforming growth factor-β, vascular endothelial factor and neuropeptide-Y. This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina.
ISSN:0042-6989
1878-5646
DOI:10.1016/j.visres.2004.12.020