Association of the Shrinking Lung Syndrome in Systemic Lupus Erythematosus with Pleurisy: A Systematic Review

Objectives To report 2 patients with systemic lupus erythematosus and typical shrinking lung syndrome (SLS) in which pleuritic chest pain was the predominant symptom. In addition, to record the prevalence of pleuritic chest pain in all reported cases of patients with SLS and diaphragmatic dysfunctio...

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Bibliographic Details
Published in:Seminars in arthritis and rheumatism 2009-08, Vol.39 (1), p.30-37
Main Authors: Toya, Sophie P., MD, Tzelepis, George E., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diaphragm - physiopathology
Diseases of the osteoarticular system
Dyspnea - diagnosis
Dyspnea - etiology
Dyspnea - physiopathology
erythematosus
Female
Humans
Lung Diseases - diagnosis
Lung Diseases - etiology
Lung Diseases - pathology
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Medical sciences
Middle Aged
Organ Size
pleurisy
Pleurisy - complications
Pleurisy - diagnosis
Pneumology
respiratory muscles
Respiratory system : syndromes and miscellaneous diseases
Rheumatology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
shrinking lung syndrome
Syndrome
systemic lupus
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Summary:Objectives To report 2 patients with systemic lupus erythematosus and typical shrinking lung syndrome (SLS) in which pleuritic chest pain was the predominant symptom. In addition, to record the prevalence of pleuritic chest pain in all reported cases of patients with SLS and diaphragmatic dysfunction. Methods We conducted a comprehensive search of the English literature to record the association of pleurisy and SLS in all reported cases using the MEDLINE database from 1965 to present. Results Of the 77 patients with SLS reported in the literature, 50 (65%) patients had pleuritic chest pain at the time of evaluation. Treatment with anti-inflammatory agents improved symptoms in the majority of cases. Conclusions Pleuritic inflammation and pain may have an important role in the pathogenesis of SLS. A possible mechanism linking pleural inflammation and diaphragm dysfunction may be via a reflex inhibition of diaphragmatic activation.
ISSN:0049-0172
1532-866X
DOI:10.1016/j.semarthrit.2008.04.003