Characterization of N(6)-cyclohexyladenosine-induced hypothermia in Syrian hamsters

The N(6)-cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature. CHA microinjection into the anterior hypothalamus (AH) elicited the...

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Bibliographic Details
Published in:Journal of pharmacological sciences 2005-03, Vol.97 (3), p.451-454
Main Authors: Shintani, Mitsuteru, Tamura, Yutaka, Monden, Mayuko, Shiomi, Hirohito
Format: Article
Language:English
Subjects:
Adenosine - analogs & derivatives
Adenosine - pharmacology
Animals
Body Temperature Regulation - drug effects
Body Temperature Regulation - physiology
Cricetinae
Hypothalamus, Anterior - drug effects
Hypothalamus, Anterior - physiology
Hypothermia, Induced
Injections, Intraventricular
Mesocricetus
Microinjections
Temperature
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Summary:The N(6)-cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature. CHA microinjection into the anterior hypothalamus (AH) elicited the most marked body temperature (T(b)) decrease compared with other regions such as the preoptic area, dorsomedial hypothalamus, posterior hypothalamus, and hippocampus. In contrast, microinjected CHA into the medial septum, ventromedial hypothalamus, and lateral hypothalamus resulted in negligible changes in T(b). These results suggest that CHA-induced hypothermia was probably due to suppression of thermogenesis via the site(s) of CHA action, viz., the AH and medial hypothalamus.
ISSN:1347-8613
DOI:10.1254/jphs.SC0040178