Nesfatin-1: An Overview and Future Clinical Application

Nesfatin/nucleobindin 2 (NUCB2) is expressed in the appetite-control hypothalamic nuclei and brainstem nuclei. Nesfatin/NUCB2 expression in the paraventricular nucleus of the hypothalamus was modulated by starvation and refeeding. Intracerebroventricular administration of nesfatin-1 dose-dependently...

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Bibliographic Details
Published in:Endocrine Journal 2009, Vol.56(4), pp.537-543
Main Authors: SHIMIZU, Hiroyuki, OH-I, Sinsuke, OKADA, Shuichi, MORI, Masatomo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Appetite Depressants - pharmacology
Body weight
Calcium-Binding Proteins - physiology
DNA-Binding Proteins - physiology
Eating - drug effects
Food intake
Leptin
Male
Mice
Mice, Obese
Molecular Sequence Data
Nerve Tissue Proteins - physiology
Nesfatin-1
Obesity
Peptide Fragments - pharmacology
Rats
Rats, Wistar
Rats, Zucker
Sequence Alignment
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Summary:Nesfatin/nucleobindin 2 (NUCB2) is expressed in the appetite-control hypothalamic nuclei and brainstem nuclei. Nesfatin/NUCB2 expression in the paraventricular nucleus of the hypothalamus was modulated by starvation and refeeding. Intracerebroventricular administration of nesfatin-1 dose-dependently inhibited food intake for 6 hours in male Wistar and leptin resistant, Zucker fatty rats. Intraperitoneal administration of nesfatin-1 and its mid-segment (M30) dosedependentlyinhibited food intake for 3 hours in male ICR mice. Intraperitoneal administration of M30 also decreased foodintake in leptin-resistant, genetically obese (ob/ob), diabetic (db/db) mice and mice fed a 45% high fat diet for 28 days. Intraperitoneal administration of M30 increased proopiomelanocortin and cocaine- and amphetamine- related peptide mRNA expression in the nucleus of the solitary tract of mice. In addition, intranasal administration of nesfatin-1 significantly inhibited food intake for 6 hours in male Wistar rats. We summarize recent observations about nesfatin-1, and attempt to present future direction of nesfatin-1 research for developing a new anti-obesity treatment.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K09E-117