Clinical implications of cortical microvasculature in adult Moyamoya disease

We analyzed cortical microvascular parameters using intraoperative ICG (Indocyaninegreen)-Videoangiography in 13 patients with Moyamoya disease, and carried out correlative studies by comparing them with clinical parameters obtained by digital subtraction angiography, physical examination, and regio...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2009-08, Vol.29 (8), p.1383-1387
Main Authors: Czabanka, Marcus, Peña-Tapia, Pablo, Schubert, Gerrit Alexander, Woitzik, Johannes, Horn, Peter, Schmiedek, Peter, Vajkoczy, Peter
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Flow Velocity - physiology
Cerebral Angiography - methods
Cerebral Cortex - blood supply
Cerebrovascular Circulation - physiology
Coloring Agents
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnosis, Computer-Assisted
Female
Humans
Indocyanine Green
Male
Medical sciences
Microcirculation - physiology
Microvessels - physiopathology
Middle Aged
Moyamoya Disease - diagnosis
Moyamoya Disease - physiopathology
Moyamoya Disease - surgery
Neurology
Vascular diseases and vascular malformations of the nervous system
Young Adult
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Summary:We analyzed cortical microvascular parameters using intraoperative ICG (Indocyaninegreen)-Videoangiography in 13 patients with Moyamoya disease, and carried out correlative studies by comparing them with clinical parameters obtained by digital subtraction angiography, physical examination, and regional cerebral blood flow studies. Patients with reduced cerebrovascular reserve capacity were characterized by increased microvascular surface area (MVSA). In addition, MVSA correlated positively with arterial microvascular transit time. Asymptomatic patients were characterized by increased arterial microvascular transit time. We show that patients with a higher arteriogenic potential to alter cortical microvasculature are characterized by a more favorable hemodynamic situation and reduced clinical symptoms.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2009.69