Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs

DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter size in Large White pigs. A total of 2,167 litter records from 420 sows genotyped at two SNP loci (LIF1 and LIF2) within LIF gene were analyzed to determine whether LIF influenc...

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Bibliographic Details
Published in:Molecular biology reports 2009-09, Vol.36 (7), p.1833-1838
Main Authors: Lin, H. C, Liu, G. F, Wang, A. G, Kong, L. J, Wang, X. F, Fu, J. L
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Animal reproduction
Animals
Biomedical and Life Sciences
Gene Frequency
Gene polymorphism
Genotype
Genotype & phenotype
Histology
Hogs
Leukemia inhibitory factor
Leukemia Inhibitory Factor - genetics
LIF1 protein
Life Sciences
Litter
Litter Size - genetics
Morphology
Parity
Parturition
Polymerase Chain Reaction
Polymorphism
Polymorphism, Single Nucleotide - genetics
Polymorphism, Single-Stranded Conformational
Single-nucleotide polymorphism
Sus scrofa - genetics
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Summary:DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter size in Large White pigs. A total of 2,167 litter records from 420 sows genotyped at two SNP loci (LIF1 and LIF2) within LIF gene were analyzed to determine whether LIF influenced total number born (TNB) and number born alive (NBA). The results indicated that B allele at LIF1 locus and A allele at LIF2 locus seem to have advantageous effects on litter size. However, the combined analyzed results demonstrated that genotype AAAA, ABBB, and BBBB are better than genotype AAAB, AABB, and ABAB for TNB and NBA in either third to eighth parity or all parities. In all parities, the sows with AAAA genotype had an advantage of 1.76 piglets (P < 0.001) for TNB and 1.44 piglets (P < 0.01) for NBA per litter over the AAAB sows, respectively. The results in this study demonstrated that LIF gene was significantly associated with litter size in pigs.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-008-9387-0