The presence of functional mannose receptor on macrophages at the maternal–fetal interface

BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined b...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2005-04, Vol.20 (4), p.1057-1066
Main Authors: Laskarin, G., Cupurdija, K., Tokmadzic, V. Sotosek, Dorcic, D., Dupor, J., Juretic, K., Strbo, N., Crncic, T. Bogovic, Marchezi, F., Allavena, P., Mantovani, A., Randic, Lj, Rukavina, D.
Format: Article
Language:English
Subjects:
Antigens, Neoplasm
Biological and medical sciences
decidua
Decidua - immunology
Decidua - metabolism
Endocytosis - immunology
Female
Flow Cytometry
Glycoproteins - pharmacokinetics
Gynecology. Andrology. Obstetrics
Humans
In Vitro Techniques
Lectins, C-Type - metabolism
Lipopolysaccharide Receptors - metabolism
macrophages
Macrophages, Peritoneal - metabolism
mannose receptor
Mannose-Binding Lectins - metabolism
Medical sciences
Phenotype
Pregnancy
Pregnancy Trimester, First - immunology
Pregnancy Trimester, First - metabolism
Progesterone - metabolism
Receptors, Cell Surface - metabolism
term pregnancy
tumor associated glycoprotein-72
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Summary:BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined by immunohistology, immunocytochemistry and flow cytometry at the maternal–fetal interface, characterized by extensive tissue remodeling. RESULTS: Contrary to disseminated distribution of the MR positive (MR+) cells in term placenta, the MR+ cells of early pregnancy decidua intimately surrounded glands and followed tissue distribution of CD14 positive cells. The mannose receptor was present on freshly isolated first trimester decidual mononuclear cells and distributed mostly on macrophages (77.08 ± 10.55%, mean ± SD). The expression of the MR on CD14 positive cells decreased following 18 h culture (P
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deh740