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The presence of functional mannose receptor on macrophages at the maternal–fetal interface

BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined b...

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Published in:	Human reproduction (Oxford) 2005-04, Vol.20 (4), p.1057-1066
Main Authors:	Laskarin, G., Cupurdija, K., Tokmadzic, V. Sotosek, Dorcic, D., Dupor, J., Juretic, K., Strbo, N., Crncic, T. Bogovic, Marchezi, F., Allavena, P., Mantovani, A., Randic, Lj, Rukavina, D.
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Language:	English
Subjects:	Antigens, Neoplasm Biological and medical sciences decidua Decidua - immunology Decidua - metabolism Endocytosis - immunology Female Flow Cytometry Glycoproteins - pharmacokinetics Gynecology. Andrology. Obstetrics Humans In Vitro Techniques Lectins, C-Type - metabolism Lipopolysaccharide Receptors - metabolism macrophages Macrophages, Peritoneal - metabolism mannose receptor Mannose-Binding Lectins - metabolism Medical sciences Phenotype Pregnancy Pregnancy Trimester, First - immunology Pregnancy Trimester, First - metabolism Progesterone - metabolism Receptors, Cell Surface - metabolism term pregnancy tumor associated glycoprotein-72
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creator	Laskarin, G. Cupurdija, K. Tokmadzic, V. Sotosek Dorcic, D. Dupor, J. Juretic, K. Strbo, N. Crncic, T. Bogovic Marchezi, F. Allavena, P. Mantovani, A. Randic, Lj Rukavina, D.
description	BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined by immunohistology, immunocytochemistry and flow cytometry at the maternal–fetal interface, characterized by extensive tissue remodeling. RESULTS: Contrary to disseminated distribution of the MR positive (MR+) cells in term placenta, the MR+ cells of early pregnancy decidua intimately surrounded glands and followed tissue distribution of CD14 positive cells. The mannose receptor was present on freshly isolated first trimester decidual mononuclear cells and distributed mostly on macrophages (77.08 ± 10.55%, mean ± SD). The expression of the MR on CD14 positive cells decreased following 18 h culture (P
doi_str_mv	10.1093/humrep/deh740
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Sotosek ; Dorcic, D. ; Dupor, J. ; Juretic, K. ; Strbo, N. ; Crncic, T. Bogovic ; Marchezi, F. ; Allavena, P. ; Mantovani, A. ; Randic, Lj ; Rukavina, D.</creator><creatorcontrib>Laskarin, G. ; Cupurdija, K. ; Tokmadzic, V. Sotosek ; Dorcic, D. ; Dupor, J. ; Juretic, K. ; Strbo, N. ; Crncic, T. Bogovic ; Marchezi, F. ; Allavena, P. ; Mantovani, A. ; Randic, Lj ; Rukavina, D.</creatorcontrib><description>BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined by immunohistology, immunocytochemistry and flow cytometry at the maternal–fetal interface, characterized by extensive tissue remodeling. RESULTS: Contrary to disseminated distribution of the MR positive (MR+) cells in term placenta, the MR+ cells of early pregnancy decidua intimately surrounded glands and followed tissue distribution of CD14 positive cells. The mannose receptor was present on freshly isolated first trimester decidual mononuclear cells and distributed mostly on macrophages (77.08 ± 10.55%, mean ± SD). The expression of the MR on CD14 positive cells decreased following 18 h culture (P<0.01) and was accompanied by the reduction of fluorescein isothiocyanate (FITC)–dextran uptake. PAM-1 anti-MR antibody, mannan and TAG-72 reduced FITC–dextran uptake by decidual macrophages. CONCLUSIONS: These data indicate that the MR+ macrophages, surrounding early decidual glands, are able to internalize ligands for carbohydrate recognition domain of the receptor, including decidual secretory phase mucin TAG-72.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deh740</identifier><identifier>PMID: 15746201</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antigens, Neoplasm ; Biological and medical sciences ; decidua ; Decidua - immunology ; Decidua - metabolism ; Endocytosis - immunology ; Female ; Flow Cytometry ; Glycoproteins - pharmacokinetics ; Gynecology. Andrology. Obstetrics ; Humans ; In Vitro Techniques ; Lectins, C-Type - metabolism ; Lipopolysaccharide Receptors - metabolism ; macrophages ; Macrophages, Peritoneal - metabolism ; mannose receptor ; Mannose-Binding Lectins - metabolism ; Medical sciences ; Phenotype ; Pregnancy ; Pregnancy Trimester, First - immunology ; Pregnancy Trimester, First - metabolism ; Progesterone - metabolism ; Receptors, Cell Surface - metabolism ; term pregnancy ; tumor associated glycoprotein-72</subject><ispartof>Human reproduction (Oxford), 2005-04, Vol.20 (4), p.1057-1066</ispartof><rights>The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Apr 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-b26c613badebb09e726605a38e217b7445a5f3b4c3a6262f1e4b58e424ccbb9e3</citedby><cites>FETCH-LOGICAL-c555t-b26c613badebb09e726605a38e217b7445a5f3b4c3a6262f1e4b58e424ccbb9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16778977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15746201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laskarin, G.</creatorcontrib><creatorcontrib>Cupurdija, K.</creatorcontrib><creatorcontrib>Tokmadzic, V. Sotosek</creatorcontrib><creatorcontrib>Dorcic, D.</creatorcontrib><creatorcontrib>Dupor, J.</creatorcontrib><creatorcontrib>Juretic, K.</creatorcontrib><creatorcontrib>Strbo, N.</creatorcontrib><creatorcontrib>Crncic, T. Bogovic</creatorcontrib><creatorcontrib>Marchezi, F.</creatorcontrib><creatorcontrib>Allavena, P.</creatorcontrib><creatorcontrib>Mantovani, A.</creatorcontrib><creatorcontrib>Randic, Lj</creatorcontrib><creatorcontrib>Rukavina, D.</creatorcontrib><title>The presence of functional mannose receptor on macrophages at the maternal–fetal interface</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined by immunohistology, immunocytochemistry and flow cytometry at the maternal–fetal interface, characterized by extensive tissue remodeling. RESULTS: Contrary to disseminated distribution of the MR positive (MR+) cells in term placenta, the MR+ cells of early pregnancy decidua intimately surrounded glands and followed tissue distribution of CD14 positive cells. The mannose receptor was present on freshly isolated first trimester decidual mononuclear cells and distributed mostly on macrophages (77.08 ± 10.55%, mean ± SD). The expression of the MR on CD14 positive cells decreased following 18 h culture (P<0.01) and was accompanied by the reduction of fluorescein isothiocyanate (FITC)–dextran uptake. PAM-1 anti-MR antibody, mannan and TAG-72 reduced FITC–dextran uptake by decidual macrophages. CONCLUSIONS: These data indicate that the MR+ macrophages, surrounding early decidual glands, are able to internalize ligands for carbohydrate recognition domain of the receptor, including decidual secretory phase mucin TAG-72.</description><subject>Antigens, Neoplasm</subject><subject>Biological and medical sciences</subject><subject>decidua</subject><subject>Decidua - immunology</subject><subject>Decidua - metabolism</subject><subject>Endocytosis - immunology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Glycoproteins - pharmacokinetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Lectins, C-Type - metabolism</subject><subject>Lipopolysaccharide Receptors - metabolism</subject><subject>macrophages</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>mannose receptor</subject><subject>Mannose-Binding Lectins - metabolism</subject><subject>Medical sciences</subject><subject>Phenotype</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - immunology</subject><subject>Pregnancy Trimester, First - metabolism</subject><subject>Progesterone - metabolism</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>term pregnancy</subject><subject>tumor associated glycoprotein-72</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqF0c1qFTEUB_AgFnutLt3KIChuxuY7M0up2pYWFKkfiBCS3DPeqTPJmGRAd30H39AnMWUGC266Sgi_c5KcP0KPCH5BcMsOd_MYYTrcwk5xfAdtCJe4pkzgu2iDqWxqQiTZR_dTusS4bBt5D-0TobikmGzQ14sdVFOEBN5BFbqqm73LffBmqEbjfUhQRXAw5RCr4MuZi2HamW-QKpOrXKpHkyEW_-fqdwe51PW-HHTGwQO015khwcN1PUAf3ry-ODqpz98enx69PK-dECLXlkonCbNmC9biFhSVEgvDGqBEWcW5MKJjljtmJJW0I8CtaIBT7py1LbAD9GzpO8XwY4aU9dgnB8NgPIQ5aakEFxzzWyFpFS1jxAU--Q9ehvn6k0lTQhrGG0UKqhdURpJShE5PsR9N_KUJ1tfh6CUcvYRT_OO16WxH2N7oNY0Cnq7AJGeGLhrv-nTjpFJNq1RxzxcX5unWO9c39inDz3_YxO9lKkwJffL5iz57pd69__jpWHP2F9gjt9g</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Laskarin, G.</creator><creator>Cupurdija, K.</creator><creator>Tokmadzic, V. 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Obstetrics</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Lectins, C-Type - metabolism</topic><topic>Lipopolysaccharide Receptors - metabolism</topic><topic>macrophages</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>mannose receptor</topic><topic>Mannose-Binding Lectins - metabolism</topic><topic>Medical sciences</topic><topic>Phenotype</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - immunology</topic><topic>Pregnancy Trimester, First - metabolism</topic><topic>Progesterone - metabolism</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>term pregnancy</topic><topic>tumor associated glycoprotein-72</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laskarin, G.</creatorcontrib><creatorcontrib>Cupurdija, K.</creatorcontrib><creatorcontrib>Tokmadzic, V. 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Bogovic</creatorcontrib><creatorcontrib>Marchezi, F.</creatorcontrib><creatorcontrib>Allavena, P.</creatorcontrib><creatorcontrib>Mantovani, A.</creatorcontrib><creatorcontrib>Randic, Lj</creatorcontrib><creatorcontrib>Rukavina, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laskarin, G.</au><au>Cupurdija, K.</au><au>Tokmadzic, V. Sotosek</au><au>Dorcic, D.</au><au>Dupor, J.</au><au>Juretic, K.</au><au>Strbo, N.</au><au>Crncic, T. Bogovic</au><au>Marchezi, F.</au><au>Allavena, P.</au><au>Mantovani, A.</au><au>Randic, Lj</au><au>Rukavina, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The presence of functional mannose receptor on macrophages at the maternal–fetal interface</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>20</volume><issue>4</issue><spage>1057</spage><epage>1066</epage><pages>1057-1066</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined by immunohistology, immunocytochemistry and flow cytometry at the maternal–fetal interface, characterized by extensive tissue remodeling. RESULTS: Contrary to disseminated distribution of the MR positive (MR+) cells in term placenta, the MR+ cells of early pregnancy decidua intimately surrounded glands and followed tissue distribution of CD14 positive cells. The mannose receptor was present on freshly isolated first trimester decidual mononuclear cells and distributed mostly on macrophages (77.08 ± 10.55%, mean ± SD). The expression of the MR on CD14 positive cells decreased following 18 h culture (P<0.01) and was accompanied by the reduction of fluorescein isothiocyanate (FITC)–dextran uptake. PAM-1 anti-MR antibody, mannan and TAG-72 reduced FITC–dextran uptake by decidual macrophages. CONCLUSIONS: These data indicate that the MR+ macrophages, surrounding early decidual glands, are able to internalize ligands for carbohydrate recognition domain of the receptor, including decidual secretory phase mucin TAG-72.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15746201</pmid><doi>10.1093/humrep/deh740</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects	Antigens, Neoplasm Biological and medical sciences decidua Decidua - immunology Decidua - metabolism Endocytosis - immunology Female Flow Cytometry Glycoproteins - pharmacokinetics Gynecology. Andrology. Obstetrics Humans In Vitro Techniques Lectins, C-Type - metabolism Lipopolysaccharide Receptors - metabolism macrophages Macrophages, Peritoneal - metabolism mannose receptor Mannose-Binding Lectins - metabolism Medical sciences Phenotype Pregnancy Pregnancy Trimester, First - immunology Pregnancy Trimester, First - metabolism Progesterone - metabolism Receptors, Cell Surface - metabolism term pregnancy tumor associated glycoprotein-72
title	The presence of functional mannose receptor on macrophages at the maternal–fetal interface
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