Biocompatibility of Poly(ε-caprolactone) Scaffold Modified by Chitosan—The Fibroblasts Proliferation in vitro

In this study, the surface of poly("-caprolactone) (PCL) scaffold was modified by chitosan (CS) in order to enhance its cell affinity and biocompatibility. It is demonstrated by scanning electronic microscopy (SEM) that when 0.5-2.0 wt% chitosan solutions are used to modify the PCL scaffold, th...

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Bibliographic Details
Published in:Journal of biomaterials applications 2005-04, Vol.19 (4), p.323-339
Main Authors: Mei, Na, Chen, Guang, Zhou, Ping, Chen, Xin, Shao, Zheng-Zhong, Pan, Luan-Feng, Wu, Chun-Gen
Format: Article
Language:English
Subjects:
Cell Adhesion - physiology
Cell Culture Techniques - methods
Cell Proliferation
Cell Survival - physiology
Cells, Cultured
Chitosan - chemistry
Coated Materials, Biocompatible - chemistry
Fibroblasts - cytology
Fibroblasts - physiology
Humans
Materials Testing
Polyesters - chemistry
Tissue Engineering - methods
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Summary:In this study, the surface of poly("-caprolactone) (PCL) scaffold was modified by chitosan (CS) in order to enhance its cell affinity and biocompatibility. It is demonstrated by scanning electronic microscopy (SEM) that when 0.5-2.0 wt% chitosan solutions are used to modify the PCL scaffold, the amount of adhesion of the fibroblasts on the chitosan-modified PCL scaffolds dramatically increase when compared to the control after 7 days cell culture. The results indicate that the chitosan-modified PCL scaffolds are more favorable for cell proliferation by improving the scaffold biocompatibility. The improvement may be helpful for the extensive applications of PCL scaffold in heart valve and blood vessel tissue engineering.
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328205048630