Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study

Aims  We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in t...

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Bibliographic Details
Published in:Diabetic medicine 2005-04, Vol.22 (4), p.387-392
Main Authors: Vendrell, J., Broch, M., Fernandez-Real, J. M., Gutiérrez, C., Simón, I., Megia, A., Gallart, L., Ricart, W., Richart, C.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Case-Control Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Diabetic Nephropathies - blood
Diabetic Nephropathies - genetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Exons
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Introns
Male
Medical sciences
Middle Aged
Mutation
nephropathy
Polymorphism, Genetic
Receptors, Tumor Necrosis Factor - blood
Receptors, Tumor Necrosis Factor - genetics
Receptors, Tumor Necrosis Factor, Type I - blood
Receptors, Tumor Necrosis Factor, Type I - genetics
Receptors, Tumor Necrosis Factor, Type II - blood
Receptors, Tumor Necrosis Factor, Type II - genetics
Solubility
TNF system
TNF2 gene polymorphisms
Type 2 diabetes
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Summary:Aims  We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in the TNFR2 gene in this population. Methods  A case‐control study was conducted to examine the role of sTNFRs in 345 DM2 patients and 173 healthy subjects. The mutations were studied in all healthy subjects and in a subset of 232 patients. Results  sTNFRs levels were similar in healthy and DM2 patients. A positive correlation between age and both sTNFRs was observed in healthy subjects. In DM2 patients, sTNFR1 showed a positive correlation with age, systolic blood pressure and leptin levels (r = 0.53, P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2004.01392.x