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Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study
Aims We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in t...
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| Published in: | Diabetic medicine 2005-04, Vol.22 (4), p.387-392 |
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| container_end_page | 392 |
| container_issue | 4 |
| container_start_page | 387 |
| container_title | Diabetic medicine |
| container_volume | 22 |
| creator | Vendrell, J. Broch, M. Fernandez-Real, J. M. Gutiérrez, C. Simón, I. Megia, A. Gallart, L. Ricart, W. Richart, C. |
| description | Aims We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in the TNFR2 gene in this population.
Methods A case‐control study was conducted to examine the role of sTNFRs in 345 DM2 patients and 173 healthy subjects. The mutations were studied in all healthy subjects and in a subset of 232 patients.
Results sTNFRs levels were similar in healthy and DM2 patients. A positive correlation between age and both sTNFRs was observed in healthy subjects. In DM2 patients, sTNFR1 showed a positive correlation with age, systolic blood pressure and leptin levels (r = 0.53, P |
| doi_str_mv | 10.1111/j.1464-5491.2004.01392.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67547137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67547137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4352-8c01bdc367fec9de9f997f2285f07ce56d6822ce49824bf85704665ee67bdf343</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhSMEokPhFZA3IFgk9V_sZMGiDG2hKkWqBrG0HOcaecgkqZ3A5GngWXgynGbUbvHGV77fObbvSRJEcEbiOtlmhAue5rwkGcWYZ5iwkmb7R8nqvvE4WWHJacqwJEfJsxC2GBNasvJpckRyWUghyCr5vRl33ehRC8Z3wQVktRk6jzwY6GMR0JvN9flNeItcizZTD3__UFQ7XcEAIUOnrW6mWdZZFLpmrBpAfaPDTiPro5Pr2oB0W6Pv0MLgDPqpvdPLcZTM1vSuN9trZHSA1HTt4LsGhWGsp-fJE6ubAC8O-3Hy9fxss_6YXn25-LQ-vUoNZzlNC4NJVRsmpAVT1lDaspSW0iK3WBrIRS0KSg3wsqC8skUuMRciBxCyqi3j7Dh5vfj2vrsdIQxq54KBptEtdGNQQuZcEiYjWCzgPK_gwareu532kyJYzeGorZozUHMGag5H3YWj9lH68nDHWO2gfhAe0ojAqwOgg9FNnGBrXHjghKBU4DJy7xbul2tg-u8HqA-fz-Yq6tNF78IA-3u99j_iP5nM1bfrC3VJ5XvC1jcqZ_8AD7G7gg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67547137</pqid></control><display><type>article</type><title>Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study</title><source>Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)</source><creator>Vendrell, J. ; Broch, M. ; Fernandez-Real, J. M. ; Gutiérrez, C. ; Simón, I. ; Megia, A. ; Gallart, L. ; Ricart, W. ; Richart, C.</creator><creatorcontrib>Vendrell, J. ; Broch, M. ; Fernandez-Real, J. M. ; Gutiérrez, C. ; Simón, I. ; Megia, A. ; Gallart, L. ; Ricart, W. ; Richart, C.</creatorcontrib><description>Aims We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in the TNFR2 gene in this population.
Methods A case‐control study was conducted to examine the role of sTNFRs in 345 DM2 patients and 173 healthy subjects. The mutations were studied in all healthy subjects and in a subset of 232 patients.
Results sTNFRs levels were similar in healthy and DM2 patients. A positive correlation between age and both sTNFRs was observed in healthy subjects. In DM2 patients, sTNFR1 showed a positive correlation with age, systolic blood pressure and leptin levels (r = 0.53, P < 0.0001; r = 0.28, P = 0.005; r = 0.46, P < 0.0001, respectively) and sTNFR2 was positively correlated with age, triglycerides and leptin levels (r = 0.34, P < 0.0001; r = 0.21, P < 0.0001; r = 0.28, P = 0.002, respectively). Patients with micro‐ or macroalbuminuria showed higher plasma levels of sTNFR1 and sTNFR2 than normoalbuminuric patients, after adjusting for confounding variables (B = 0.85, P = 0.022, 95% CI: 0.12–1.58 for sTNFR1 and B = 1.50, P < 0.001, 95% CI: 0.67–2.33 for sTNFR2). In DM2 patients, TT‐exon 6 homozygous showed lower levels of sTNFR1 [2,4 (1.1) vs. 3.4 (1.2) ng/ml], and the CA273‐allele tracked with elevated plasma HDL‐cholesterol [1.8 (0.7), 1.4 (0.3) and 1.3 (0.3) mm, for CA273/273, CA273/– and CA–/–, respectively]. No association was seen with other analysed variables.
Conclusions Our findings suggest that chronic TNF activation may have some pathogenic role in diabetic nephropathy in DM2 patients. Genetic variations in exon 6/intron 4 of the TNFR2 gene do not predispose to a major risk for DM2 or its microvascular complications</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2004.01392.x</identifier><identifier>PMID: 15787661</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - genetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Exons ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Introns ; Male ; Medical sciences ; Middle Aged ; Mutation ; nephropathy ; Polymorphism, Genetic ; Receptors, Tumor Necrosis Factor - blood ; Receptors, Tumor Necrosis Factor - genetics ; Receptors, Tumor Necrosis Factor, Type I - blood ; Receptors, Tumor Necrosis Factor, Type I - genetics ; Receptors, Tumor Necrosis Factor, Type II - blood ; Receptors, Tumor Necrosis Factor, Type II - genetics ; Solubility ; TNF system ; TNF2 gene polymorphisms ; Type 2 diabetes</subject><ispartof>Diabetic medicine, 2005-04, Vol.22 (4), p.387-392</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4352-8c01bdc367fec9de9f997f2285f07ce56d6822ce49824bf85704665ee67bdf343</citedby><cites>FETCH-LOGICAL-c4352-8c01bdc367fec9de9f997f2285f07ce56d6822ce49824bf85704665ee67bdf343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16622609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15787661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vendrell, J.</creatorcontrib><creatorcontrib>Broch, M.</creatorcontrib><creatorcontrib>Fernandez-Real, J. M.</creatorcontrib><creatorcontrib>Gutiérrez, C.</creatorcontrib><creatorcontrib>Simón, I.</creatorcontrib><creatorcontrib>Megia, A.</creatorcontrib><creatorcontrib>Gallart, L.</creatorcontrib><creatorcontrib>Ricart, W.</creatorcontrib><creatorcontrib>Richart, C.</creatorcontrib><title>Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in the TNFR2 gene in this population.
Methods A case‐control study was conducted to examine the role of sTNFRs in 345 DM2 patients and 173 healthy subjects. The mutations were studied in all healthy subjects and in a subset of 232 patients.
Results sTNFRs levels were similar in healthy and DM2 patients. A positive correlation between age and both sTNFRs was observed in healthy subjects. In DM2 patients, sTNFR1 showed a positive correlation with age, systolic blood pressure and leptin levels (r = 0.53, P < 0.0001; r = 0.28, P = 0.005; r = 0.46, P < 0.0001, respectively) and sTNFR2 was positively correlated with age, triglycerides and leptin levels (r = 0.34, P < 0.0001; r = 0.21, P < 0.0001; r = 0.28, P = 0.002, respectively). Patients with micro‐ or macroalbuminuria showed higher plasma levels of sTNFR1 and sTNFR2 than normoalbuminuric patients, after adjusting for confounding variables (B = 0.85, P = 0.022, 95% CI: 0.12–1.58 for sTNFR1 and B = 1.50, P < 0.001, 95% CI: 0.67–2.33 for sTNFR2). In DM2 patients, TT‐exon 6 homozygous showed lower levels of sTNFR1 [2,4 (1.1) vs. 3.4 (1.2) ng/ml], and the CA273‐allele tracked with elevated plasma HDL‐cholesterol [1.8 (0.7), 1.4 (0.3) and 1.3 (0.3) mm, for CA273/273, CA273/– and CA–/–, respectively]. No association was seen with other analysed variables.
Conclusions Our findings suggest that chronic TNF activation may have some pathogenic role in diabetic nephropathy in DM2 patients. Genetic variations in exon 6/intron 4 of the TNFR2 gene do not predispose to a major risk for DM2 or its microvascular complications</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Exons</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Introns</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>nephropathy</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Receptors, Tumor Necrosis Factor - genetics</subject><subject>Receptors, Tumor Necrosis Factor, Type I - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type I - genetics</subject><subject>Receptors, Tumor Necrosis Factor, Type II - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type II - genetics</subject><subject>Solubility</subject><subject>TNF system</subject><subject>TNF2 gene polymorphisms</subject><subject>Type 2 diabetes</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhSMEokPhFZA3IFgk9V_sZMGiDG2hKkWqBrG0HOcaecgkqZ3A5GngWXgynGbUbvHGV77fObbvSRJEcEbiOtlmhAue5rwkGcWYZ5iwkmb7R8nqvvE4WWHJacqwJEfJsxC2GBNasvJpckRyWUghyCr5vRl33ehRC8Z3wQVktRk6jzwY6GMR0JvN9flNeItcizZTD3__UFQ7XcEAIUOnrW6mWdZZFLpmrBpAfaPDTiPro5Pr2oB0W6Pv0MLgDPqpvdPLcZTM1vSuN9trZHSA1HTt4LsGhWGsp-fJE6ubAC8O-3Hy9fxss_6YXn25-LQ-vUoNZzlNC4NJVRsmpAVT1lDaspSW0iK3WBrIRS0KSg3wsqC8skUuMRciBxCyqi3j7Dh5vfj2vrsdIQxq54KBptEtdGNQQuZcEiYjWCzgPK_gwareu532kyJYzeGorZozUHMGag5H3YWj9lH68nDHWO2gfhAe0ojAqwOgg9FNnGBrXHjghKBU4DJy7xbul2tg-u8HqA-fz-Yq6tNF78IA-3u99j_iP5nM1bfrC3VJ5XvC1jcqZ_8AD7G7gg</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Vendrell, J.</creator><creator>Broch, M.</creator><creator>Fernandez-Real, J. M.</creator><creator>Gutiérrez, C.</creator><creator>Simón, I.</creator><creator>Megia, A.</creator><creator>Gallart, L.</creator><creator>Ricart, W.</creator><creator>Richart, C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study</title><author>Vendrell, J. ; Broch, M. ; Fernandez-Real, J. M. ; Gutiérrez, C. ; Simón, I. ; Megia, A. ; Gallart, L. ; Ricart, W. ; Richart, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4352-8c01bdc367fec9de9f997f2285f07ce56d6822ce49824bf85704665ee67bdf343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Exons</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Introns</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>nephropathy</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Receptors, Tumor Necrosis Factor - genetics</topic><topic>Receptors, Tumor Necrosis Factor, Type I - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type I - genetics</topic><topic>Receptors, Tumor Necrosis Factor, Type II - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type II - genetics</topic><topic>Solubility</topic><topic>TNF system</topic><topic>TNF2 gene polymorphisms</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vendrell, J.</creatorcontrib><creatorcontrib>Broch, M.</creatorcontrib><creatorcontrib>Fernandez-Real, J. M.</creatorcontrib><creatorcontrib>Gutiérrez, C.</creatorcontrib><creatorcontrib>Simón, I.</creatorcontrib><creatorcontrib>Megia, A.</creatorcontrib><creatorcontrib>Gallart, L.</creatorcontrib><creatorcontrib>Ricart, W.</creatorcontrib><creatorcontrib>Richart, C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vendrell, J.</au><au>Broch, M.</au><au>Fernandez-Real, J. M.</au><au>Gutiérrez, C.</au><au>Simón, I.</au><au>Megia, A.</au><au>Gallart, L.</au><au>Ricart, W.</au><au>Richart, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2005-04</date><risdate>2005</risdate><volume>22</volume><issue>4</issue><spage>387</spage><epage>392</epage><pages>387-392</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims We have studied the relationships between soluble fractions of tumour necrosis factor receptors (sTNFR1 and sTNFR2) in Type 2 diabetes (DM2) and its chronic microvascular complications. Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA‐repeat intron 4 mutations in the TNFR2 gene in this population.
Methods A case‐control study was conducted to examine the role of sTNFRs in 345 DM2 patients and 173 healthy subjects. The mutations were studied in all healthy subjects and in a subset of 232 patients.
Results sTNFRs levels were similar in healthy and DM2 patients. A positive correlation between age and both sTNFRs was observed in healthy subjects. In DM2 patients, sTNFR1 showed a positive correlation with age, systolic blood pressure and leptin levels (r = 0.53, P < 0.0001; r = 0.28, P = 0.005; r = 0.46, P < 0.0001, respectively) and sTNFR2 was positively correlated with age, triglycerides and leptin levels (r = 0.34, P < 0.0001; r = 0.21, P < 0.0001; r = 0.28, P = 0.002, respectively). Patients with micro‐ or macroalbuminuria showed higher plasma levels of sTNFR1 and sTNFR2 than normoalbuminuric patients, after adjusting for confounding variables (B = 0.85, P = 0.022, 95% CI: 0.12–1.58 for sTNFR1 and B = 1.50, P < 0.001, 95% CI: 0.67–2.33 for sTNFR2). In DM2 patients, TT‐exon 6 homozygous showed lower levels of sTNFR1 [2,4 (1.1) vs. 3.4 (1.2) ng/ml], and the CA273‐allele tracked with elevated plasma HDL‐cholesterol [1.8 (0.7), 1.4 (0.3) and 1.3 (0.3) mm, for CA273/273, CA273/– and CA–/–, respectively]. No association was seen with other analysed variables.
Conclusions Our findings suggest that chronic TNF activation may have some pathogenic role in diabetic nephropathy in DM2 patients. Genetic variations in exon 6/intron 4 of the TNFR2 gene do not predispose to a major risk for DM2 or its microvascular complications</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15787661</pmid><doi>10.1111/j.1464-5491.2004.01392.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Case-Control Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Diabetic Nephropathies - blood Diabetic Nephropathies - genetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Exons Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Introns Male Medical sciences Middle Aged Mutation nephropathy Polymorphism, Genetic Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor, Type I - blood Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type II - blood Receptors, Tumor Necrosis Factor, Type II - genetics Solubility TNF system TNF2 gene polymorphisms Type 2 diabetes |
| title | Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study |
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