Adiponectin Replacement Therapy Attenuates Myocardial Damage in Leptin-deficient Mice with Viral Myocarditis

The effects of adiponectin replacement therapy on myocardial damage were studied in leptin-deficient (OB) mice with acute viral myocarditis. Encephalomyocarditis virus was injected intraperitoneally into OB and wild-type (WT) mice. One subgroup of OB mice received no intervention and another subgrou...

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Bibliographic Details
Published in:Journal of international medical research 2005-03, Vol.33 (2), p.207-214
Main Authors: Takahashi, T, Saegusa, S, Sumino, H, Nakahashi, T, Iwai, K, Morimoto, S, Kanda, T
Format: Article
Language:English
Subjects:
Adiponectin
Animals
Apoptosis
Body Weight
Disease Progression
Encephalomyocarditis virus - metabolism
Genetic Therapy
Heart - physiology
Heart - virology
Intercellular Signaling Peptides and Proteins - administration & dosage
Intercellular Signaling Peptides and Proteins - metabolism
Leptin - metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Muscle Cells - metabolism
Myocarditis - therapy
Myocarditis - virology
Myocardium - metabolism
Myocardium - pathology
Organ Size
Protein Binding
Receptors, Adiponectin
Receptors, Cell Surface - metabolism
Receptors, Leptin
Time Factors
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Summary:The effects of adiponectin replacement therapy on myocardial damage were studied in leptin-deficient (OB) mice with acute viral myocarditis. Encephalomyocarditis virus was injected intraperitoneally into OB and wild-type (WT) mice. One subgroup of OB mice received no intervention and another subgroup received daily adiponectin replacement, simultaneously with viral inoculation. Differences in heart weight, cardiac histological score, numbers of infiltrating or apoptotic cells in the myocardium and the immunoreactivity of adiponectin receptors in myocytes were determined. The reactivity of adiponectin receptor 1 in myocytes from OB mice on day 4 and day 8 after viral inoculation was significantly decreased compared with that in myocytes from WT mice; the OB mice also had elevated cardiac weights and severe inflammatory myocardial damage. Adiponectin replacement in OB mice inhibited the development of severe myocarditis by augmenting myocyte adiponectin receptor 1 reactivity. Exogenously administered adiponectin may inhibit the progression of viral myocarditis through binding to the adiponectin receptor 1 in leptin-deficient conditions.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000503300208