Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper

Abstract Young mink kits ( n = 8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodies were induced after 2 immunisations and after the third immunisation all kits had high VN antibody...

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Bibliographic Details
Published in:Vaccine 2009-08, Vol.27 (38), p.5178-5183
Main Authors: Jensen, Trine Hammer, Nielsen, Line, Aasted, Bent, Blixenkrone-Møller, Merete
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies
Antibodies, Viral - blood
Antibodies, Viral - immunology
Antigens
Applied microbiology
Biological and medical sciences
Canine distemper virus
Cercopithecus aethiops
Deoxyribonucleic acid
Distemper - immunology
Distemper - prevention & control
Distemper Virus, Canine - immunology
DNA
DNA vaccination
Dogs
Early life vaccination
Fundamental and applied biological sciences. Psychology
Genes
Hemagglutinins, Viral - immunology
Immunization
Infections
Injections
Interferon-gamma - immunology
Microbiology
Mink - immunology
Mink - virology
Miscellaneous
Neutralization Tests
Plasmids
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - immunology
Vero Cells
Viral Vaccines - immunology
Virology
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Summary:Abstract Young mink kits ( n = 8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodies were induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-γ producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.06.077