HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong

Ligusticum chuanxiong Hort., a plant that is frequently used in traditional Chinese medicine, has been studied using HPLC-coupled spectroscopic techniques such as HPLC-UV, HPLC-MS as well as HPLC-NMR. With the aid of these modern spectroscopic techniques, the main constituents, namely senkyunolide A...

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Bibliographic Details
Published in:Molecular diversity 2005, Vol.9 (1-3), p.33-39
Main Authors: Zschocke, S, Klaiber, I, Bauer, R, Vogler, B
Format: Article
Language:English
Subjects:
Acupuncture
Chinese medicine
Chromatography, High Pressure Liquid - methods
Gas Chromatography-Mass Spectrometry
Ligusticum - chemistry
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medicine, Chinese Traditional
Models, Molecular
Phthalic Acids - chemistry
Phthalic Acids - isolation & purification
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Spectrophotometry, Ultraviolet
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Summary:Ligusticum chuanxiong Hort., a plant that is frequently used in traditional Chinese medicine, has been studied using HPLC-coupled spectroscopic techniques such as HPLC-UV, HPLC-MS as well as HPLC-NMR. With the aid of these modern spectroscopic techniques, the main constituents, namely senkyunolide A, butylphthalide, neocnidilide and Z-ligustilide, have been characterized and identified. Phthalide dimers, present in smaller amounts, have been identified by HPLC-UV and HPLC-MS analysis and compared with reference compounds. Stereochemical features of some phthalide monomers have been determined by detailed spectroscopic studies for the first time.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-005-1305-y