Open lung biopsy in pediatric patients with respiratory failure after abdominal transplantation

:  To understand the utility of open lung biopsy (OLB) in the evaluation of respiratory failure in pediatric abdominal organ transplant we reviewed the records of nine children in this patient population who underwent an OLB. Eight of nine patients had undergone a previous non‐diagnostic bronchoalve...

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Bibliographic Details
Published in:Pediatric transplantation 2005-04, Vol.9 (2), p.197-200
Main Authors: Vendryes III, Christopher, McLaughlin, Gwenn E., Romaguera, Rita L., Sola, Juan, Kato, Tomoaki
Format: Article
Language:English
Subjects:
Adenovirus
Adolescent
Biological and medical sciences
biopsy
Biopsy - adverse effects
Biopsy - methods
Child
Child, Preschool
Epstein-Barr virus infections
General aspects
graft-vs.-host disease
Humans
Infant
interstitial
intestinal transplantation
Intestines - transplantation
liver transplantation
Lung - pathology
lung diseases
Medical sciences
Pneumology
respiratory insufficiency
Respiratory Insufficiency - etiology
Respiratory Insufficiency - pathology
Respiratory syncytial virus
Respiratory system : syndromes and miscellaneous diseases
Retrospective Studies
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Summary::  To understand the utility of open lung biopsy (OLB) in the evaluation of respiratory failure in pediatric abdominal organ transplant we reviewed the records of nine children in this patient population who underwent an OLB. Eight of nine patients had undergone a previous non‐diagnostic bronchoalveolar lavage. Biopsies were performed at the bedside in the pediatric intensive care unit and tissue was processed by the Department of Pathology with special stains for infectious agents. There were no significant complications of OLB. A specific treatable etiology was identified in four patients (respiratory syncytial virus, adenovirus, graft‐vs.‐host disease and post‐transplant lymphoproliferative disease), leading to a change in therapy and survival in two. Overall survival was 44%. Given the low morbidity, OLB as performed in this study appears appropriate in this patient population.
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2004.00283.x