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Why Chlamydia pneumoniae is associated with asthma and other chronic conditions? Suggestions from a survey in unselected 9 yr old schoolchildren
Despite numerous studies demonstrating an association between asthma and many other chronic conditions and signs of Chlamydia pneumoniae (Cp) infection, the role of Cp in the pathogenesis of these illness remain still unclear. We investigated the prevalence of Cp antigen in the upper airways and the...
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Published in: | Pediatric allergy and immunology 2005-03, Vol.16 (2), p.145-150 |
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description | Despite numerous studies demonstrating an association between asthma and many other chronic conditions and signs of Chlamydia pneumoniae (Cp) infection, the role of Cp in the pathogenesis of these illness remain still unclear. We investigated the prevalence of Cp antigen in the upper airways and the prevalence of detectable Cp serum antibodies in an unselected population of 207 9‐yr‐old schoolchildren. We also sought the presence of asthma, chronic or recurrent respiratory symptoms by means of questionnaire completed by the parents. Nasal aspirate, blood sampling and allergen skin prick tests were also performed. None of the children had obvious signs of acute infection at physical examination. Cp DNA was detected in nasal aspirates from 20 of the 207 children tested and serum IgG antibodies for Cp in 68 children. No association was found between atopy or history of atopic illness and the presence of Cp DNA or antibody production. This finding is explained by the fact that our study was conducted in an unselected childhood population, inherently including few children with asthma. A strong association between the status of antigen carrier and the presence of detectable Cp serum immunoglobulin (Ig)G or IgM suggests that subjects with detectable Cp antibodies have an impaired ability to eliminate this pathogen when infected. Because Cp eradication requires a strong Th1 lymphocyte response, the previously proven association between Cp and asthma, might reflect the known association of asthma with Th2‐oriented lymphocytic activity. |
doi_str_mv | 10.1111/j.1399-3038.2005.00244.x |
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We also sought the presence of asthma, chronic or recurrent respiratory symptoms by means of questionnaire completed by the parents. Nasal aspirate, blood sampling and allergen skin prick tests were also performed. None of the children had obvious signs of acute infection at physical examination. Cp DNA was detected in nasal aspirates from 20 of the 207 children tested and serum IgG antibodies for Cp in 68 children. No association was found between atopy or history of atopic illness and the presence of Cp DNA or antibody production. This finding is explained by the fact that our study was conducted in an unselected childhood population, inherently including few children with asthma. A strong association between the status of antigen carrier and the presence of detectable Cp serum immunoglobulin (Ig)G or IgM suggests that subjects with detectable Cp antibodies have an impaired ability to eliminate this pathogen when infected. 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Suggestions from a survey in unselected 9 yr old schoolchildren</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Despite numerous studies demonstrating an association between asthma and many other chronic conditions and signs of Chlamydia pneumoniae (Cp) infection, the role of Cp in the pathogenesis of these illness remain still unclear. We investigated the prevalence of Cp antigen in the upper airways and the prevalence of detectable Cp serum antibodies in an unselected population of 207 9‐yr‐old schoolchildren. We also sought the presence of asthma, chronic or recurrent respiratory symptoms by means of questionnaire completed by the parents. Nasal aspirate, blood sampling and allergen skin prick tests were also performed. None of the children had obvious signs of acute infection at physical examination. Cp DNA was detected in nasal aspirates from 20 of the 207 children tested and serum IgG antibodies for Cp in 68 children. No association was found between atopy or history of atopic illness and the presence of Cp DNA or antibody production. This finding is explained by the fact that our study was conducted in an unselected childhood population, inherently including few children with asthma. A strong association between the status of antigen carrier and the presence of detectable Cp serum immunoglobulin (Ig)G or IgM suggests that subjects with detectable Cp antibodies have an impaired ability to eliminate this pathogen when infected. Because Cp eradication requires a strong Th1 lymphocyte response, the previously proven association between Cp and asthma, might reflect the known association of asthma with Th2‐oriented lymphocytic activity.</description><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens, Bacterial - analysis</subject><subject>asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>children</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia Infections - immunology</subject><subject>Chlamydia pneumoniae</subject><subject>Chlamydophila pneumoniae</subject><subject>Chlamydophila pneumoniae - genetics</subject><subject>Chlamydophila pneumoniae - immunology</subject><subject>Chronic Disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>DNA</subject><subject>DNA - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - epidemiology</subject><subject>Hypersensitivity, Immediate - etiology</subject><subject>Immunoglobulin G - blood</subject><subject>Immunopathology</subject><subject>infection</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasal Mucosa - microbiology</subject><subject>Pneumology</subject><subject>Polymerase Chain Reaction</subject><subject>serum antibodies</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQxiNERZfCKyBf4JZgx3EcS0ioXUGpWgHij4q4WF570nhJ4sVO6OaGxBvwiDwJTnfVHsFzsMf-fePRfEmCCM5IXM_XGaFCpBTTKssxZhnGeVFk23vJ4vbhfrLAArO0JIwfJg9DWGNMOC3Jg-QwXlUx8kXy-7KZ0LJpVTcZq9Cmh7FzvVWAbEAqBKetGsCgazs0MR-aTiHVG-SGBjzSjY-wRtr1xg7W9eEl-jheXUG4SVDtXYcUCqP_AROyPRr7AC3ouaL48_PX5JFrDQq6ca7VjW2Nh_5RclCrNsDj_X6UfH796tPyTXrx7vRseXyR6qJkRWoKAZiC4SsteL1SvMakAl2xXNc5IRxj0CvMcsUMrQtTG41VyYkgORSM54oeJc92dTfefR9jy7KzQUPbqh7cGGTJGcMVw_8EiRCcUS4iWO1A7V0IHmq58bZTfpIEy9k4uZazP3L2R87GyRvj5DZKn-z_GFcdmDvh3qkIPN0DKmjV1l712oY7riwpJmLmXuy4a9vC9N8NyPfHZ_EQ5elObsMA21u58t_iPChn8vLtqVzSrx_OTwiXX-hfTgLGtQ</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Ronchetti, Roberto</creator><creator>Biscione, Gian Luca</creator><creator>Ronchetti, Francesco</creator><creator>Ronchetti, Maria Paola</creator><creator>Martella, Susy</creator><creator>Falasca, Carlo</creator><creator>Casini, Carolina</creator><creator>Barreto, Mario</creator><creator>Villa, Maria Pia</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Why Chlamydia pneumoniae is associated with asthma and other chronic conditions? Suggestions from a survey in unselected 9 yr old schoolchildren</title><author>Ronchetti, Roberto ; Biscione, Gian Luca ; Ronchetti, Francesco ; Ronchetti, Maria Paola ; Martella, Susy ; Falasca, Carlo ; Casini, Carolina ; Barreto, Mario ; Villa, Maria Pia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4654-d49e03ed7bc97fba7f018ec852cf211700ecb052a5d3f4dfdc0a671912e4572a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens, Bacterial - analysis</topic><topic>asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>children</topic><topic>Chlamydia Infections - complications</topic><topic>Chlamydia Infections - immunology</topic><topic>Chlamydia pneumoniae</topic><topic>Chlamydophila pneumoniae</topic><topic>Chlamydophila pneumoniae - genetics</topic><topic>Chlamydophila pneumoniae - immunology</topic><topic>Chronic Disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>DNA</topic><topic>DNA - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - epidemiology</topic><topic>Hypersensitivity, Immediate - etiology</topic><topic>Immunoglobulin G - blood</topic><topic>Immunopathology</topic><topic>infection</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Mucosa - microbiology</topic><topic>Pneumology</topic><topic>Polymerase Chain Reaction</topic><topic>serum antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ronchetti, Roberto</creatorcontrib><creatorcontrib>Biscione, Gian Luca</creatorcontrib><creatorcontrib>Ronchetti, Francesco</creatorcontrib><creatorcontrib>Ronchetti, Maria Paola</creatorcontrib><creatorcontrib>Martella, Susy</creatorcontrib><creatorcontrib>Falasca, Carlo</creatorcontrib><creatorcontrib>Casini, Carolina</creatorcontrib><creatorcontrib>Barreto, Mario</creatorcontrib><creatorcontrib>Villa, Maria Pia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ronchetti, Roberto</au><au>Biscione, Gian Luca</au><au>Ronchetti, Francesco</au><au>Ronchetti, Maria Paola</au><au>Martella, Susy</au><au>Falasca, Carlo</au><au>Casini, Carolina</au><au>Barreto, Mario</au><au>Villa, Maria Pia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Why Chlamydia pneumoniae is associated with asthma and other chronic conditions? Suggestions from a survey in unselected 9 yr old schoolchildren</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2005-03</date><risdate>2005</risdate><volume>16</volume><issue>2</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Despite numerous studies demonstrating an association between asthma and many other chronic conditions and signs of Chlamydia pneumoniae (Cp) infection, the role of Cp in the pathogenesis of these illness remain still unclear. We investigated the prevalence of Cp antigen in the upper airways and the prevalence of detectable Cp serum antibodies in an unselected population of 207 9‐yr‐old schoolchildren. We also sought the presence of asthma, chronic or recurrent respiratory symptoms by means of questionnaire completed by the parents. Nasal aspirate, blood sampling and allergen skin prick tests were also performed. None of the children had obvious signs of acute infection at physical examination. Cp DNA was detected in nasal aspirates from 20 of the 207 children tested and serum IgG antibodies for Cp in 68 children. No association was found between atopy or history of atopic illness and the presence of Cp DNA or antibody production. This finding is explained by the fact that our study was conducted in an unselected childhood population, inherently including few children with asthma. A strong association between the status of antigen carrier and the presence of detectable Cp serum immunoglobulin (Ig)G or IgM suggests that subjects with detectable Cp antibodies have an impaired ability to eliminate this pathogen when infected. Because Cp eradication requires a strong Th1 lymphocyte response, the previously proven association between Cp and asthma, might reflect the known association of asthma with Th2‐oriented lymphocytic activity.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15787872</pmid><doi>10.1111/j.1399-3038.2005.00244.x</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Antibodies, Bacterial - blood Antigens, Bacterial - analysis asthma Asthma - epidemiology Asthma - etiology atopy Biological and medical sciences Child children Chlamydia Infections - complications Chlamydia Infections - immunology Chlamydia pneumoniae Chlamydophila pneumoniae Chlamydophila pneumoniae - genetics Chlamydophila pneumoniae - immunology Chronic Disease Chronic obstructive pulmonary disease, asthma DNA DNA - analysis Female Humans Hypersensitivity, Immediate - epidemiology Hypersensitivity, Immediate - etiology Immunoglobulin G - blood Immunopathology infection Male Medical sciences Nasal Mucosa - microbiology Pneumology Polymerase Chain Reaction serum antibodies |
title | Why Chlamydia pneumoniae is associated with asthma and other chronic conditions? Suggestions from a survey in unselected 9 yr old schoolchildren |
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