Biocompatibility of Poly(carbonate urethane)s with Various Degrees of Nanophase Separation

• Published in: Macromolecular bioscience 2005-03, Vol.5 (3), p.246-253
• Main Authors: Hsu, Shan-hui, Kao, Yu-Chih
• Format: Article
• Language: English
• Subjects: Applied sciences; Bacillus subtilis - drug effects; bacterial adhesion; Biocompatible Materials - isolation & purification; Biocompatible Materials - pharmacology; Biological properties; Blood Cells - drug effects; Blood Physiological Phenomena - drug effects; Exact sciences and technology; Humans; monocyte activation; nanophase separation; Nanotechnology; Organic polymers; phase separation; Physicochemistry of polymers; platelet activation; platelet adhesion; poly(carbonate urethane); Polyurethanes - isolation & purification; Polyurethanes - pharmacology; Properties and characterization
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.200400163

Nanophase separation has been suggested to influence the biological performance of polyurethane. In a previous work (Macromol. Biosci. 2004, 4, 891), six different 4,4′‐diphenylmethane diisocyanate (MDI)‐based poly(carbonate urethane)s (PCUs) that exhibited various degrees of nanophase separation were synthesized and characterized. In the present work, these PCUs were used as a model system to study the effect of nanometric structures on the biocompatibility of polyurethane. Human blood platelet activation, monocyte activation, protein adsorption, and bacterial adhesion on PCU were investigated in vitro. It was found that human blood platelets as well as monocytes were less activated on the PCU surfaces with a greater degree of nanophase separation in general. This phenomenon was closely associated with the lower ratio of human fibrinogen/albumin competitively adsorbed on these surfaces. Bacterial adhesion was also inhibited in some nanophase‐separated PCUs. The morphology of a platelet on a PCU studied here.