Immunoglobulin M Myeloma: Evaluation of Molecular Features and Cytokine Expression

Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenström's macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal–center in origin wit...

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Bibliographic Details
Published in:Clinical lymphoma 2005-03, Vol.5 (4), p.285-289
Main Authors: Konduri, Kartik, Sahota, Surinder S., Babbage, Gavin, Tong, Alex W., Kumar, Padmasini, Newman, Joseph T., Stone, Marvin J.
Format: Article
Language:English
Subjects:
Cell Differentiation
Cytokines - biosynthesis
Glycoproteins - biosynthesis
Humans
Immunoglobulin M - genetics
Immunoglobulin M - immunology
Lymphokines - biosynthesis
Male
Middle Aged
Multiple Myeloma - genetics
Multiple Myeloma - immunology
Osteoclast-activating factor
Osteoprotegerin
Plasma cell dyscrasias
Receptors, Cytoplasmic and Nuclear - biosynthesis
Receptors, Tumor Necrosis Factor
Translocation, Genetic
Tumor VH gene
Waldenstrom Macroglobulinemia - genetics
Waldenstrom Macroglobulinemia - immunology
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Summary:Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenström's macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal–center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and MM. Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.
ISSN:1526-9655
2331-4486
DOI:10.3816/CLM.2005.n.018