Choroidal perfusion measurements made with optical coherence tomography

Choroidal perfusion measurements are complicated by the choroid's location posterior to the retina and its associated retinal blood vessels. Optical coherence tomography is a relatively new imaging technique with sufficient spatial resolution to isolate choroidal backscattering events from the...

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Bibliographic Details
Published in:Applied optics (2004) 2005-03, Vol.44 (8), p.1426-1433
Main Authors: Wu, Frank I, Glucksberg, Matthew R
Format: Article
Language:English
Subjects:
Algorithms
Animals
Artificial Intelligence
Blood Flow Velocity - physiology
Choroid - blood supply
Choroid - cytology
Choroid - physiology
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Information Storage and Retrieval - methods
Ophthalmoscopy - methods
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
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Description
Summary:Choroidal perfusion measurements are complicated by the choroid's location posterior to the retina and its associated retinal blood vessels. Optical coherence tomography is a relatively new imaging technique with sufficient spatial resolution to isolate choroidal backscattering events from the posterior eye. We modified a speckle imaging algorithm to analyze sequential axial depth scans obtained from posterior rat eye to obtain an indicator of choroidal perfusion. This indicator is correlated with known changes in choroidal blood flow in response to increased intraocular pressure.
ISSN:1559-128X
DOI:10.1364/AO.44.001426